PYY3-36 inhibited food intake in MC4R knockout mice (which are obese), proving its satiety mechanism doesn't require the melanocortin-4 receptor and works independently of the alpha-MSH satiety pathway.
Key findingPYY3-36 inhibited food intake in MC4R knockout mice, demonstrating a melanocortin-4 receptor-independent satiety mechanism and establishing PYY as an
What the researchers found
PYY3-36 inhibited food intake in MC4R knockout mice, demonstrating a melanocortin-4 receptor-independent satiety mechanism and establishing PYY as an independent appetite-suppressing pathway from the alpha-MSH system.
Why it matters
Advances understanding in neuropeptides, weight-loss, receptor-signaling research.
How the study worked
animal-study study. Details in abstract.
What this study cannot tell us
See abstract for study-specific limitations.
How to read the evidence
preliminary evidence from animal-study study.
When this study was published
Published in 2004.
The bigger picture
Contributes to the growing body of evidence in peptide research.
Questions still open
- Further research needed to confirm and extend findings.
- Clinical translation potential to be evaluated.
Common questions
What was studied?
What was found?
Read the original research
Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism.
Endocrinology, 145(6), 2585-90
Citation
Halatchev, Ilia G; Ellacott, Kate L J; Fan, Wei; Cone, Roger D. (2004). Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism.. Endocrinology, 145(6), 2585-90.