PYY3-36 Suppresses Appetite Through a Pathway Independent of the Melanocortin-4 Receptor
PYY3-36 inhibited food intake in MC4R knockout mice (which are obese), proving its satiety mechanism doesn't require the melanocortin-4 receptor and works independently of the alpha-MSH satiety pathway.
Quick Facts
What This Study Found
PYY3-36 inhibited food intake in MC4R knockout mice, demonstrating a melanocortin-4 receptor-independent satiety mechanism and establishing PYY as an independent appetite-suppressing pathway from the alpha-MSH system.
Key Numbers
How They Did This
animal-study study. Details in abstract.
Why This Research Matters
Advances understanding in neuropeptides, weight-loss, receptor-signaling research.
The Bigger Picture
Contributes to the growing body of evidence in peptide research.
What This Study Doesn't Tell Us
See abstract for study-specific limitations.
Questions This Raises
- ?Further research needed to confirm and extend findings.
- ?Clinical translation potential to be evaluated.
Trust & Context
- Key Stat:
- Key finding PYY3-36 inhibited food intake in MC4R knockout mice, demonstrating a melanocortin-4 receptor-independent satiety mechanism and establishing PYY as an
- Evidence Grade:
- preliminary evidence from animal-study study.
- Study Age:
- Published in 2004.
- Original Title:
- Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism.
- Published In:
- Endocrinology, 145(6), 2585-90 (2004)
- Authors:
- Halatchev, Ilia G(3), Ellacott, Kate L J(2), Fan, Wei, Cone, Roger D
- Database ID:
- RPEP-00919
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
PYY3-36 Suppresses Appetite Through a Pathway Independent of the Melanocortin-4 Receptor
What was found?
PYY3-36 inhibited food intake in MC4R knockout mice (which are obese), proving its satiety mechanism doesn't require the melanocortin-4 receptor and works independently of the alpha-MSH satiety pathway.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00919APA
Halatchev, Ilia G; Ellacott, Kate L J; Fan, Wei; Cone, Roger D. (2004). Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism.. Endocrinology, 145(6), 2585-90.
MLA
Halatchev, Ilia G, et al. "Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism.." Endocrinology, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Peptide YY3-36 inhibits food intake in mice through a melano..." RPEP-00919. Retrieved from https://rethinkpeptides.com/research/halatchev-2004-peptide-yy336-inhibits-food
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.