PYY's roles extend beyond appetite suppression to comprehensive gut physiology regulation: gastric emptying, intestinal motility, pancreatic secretion, and fluid absorption — with PYY deficiency contributing to obesity.
Key findingPYY integrates multiple gut functions: suppresses appetite (Y2R-mediated), slows gastric emptying, reduces intestinal motility, decreases pancreatic s
What the researchers found
PYY integrates multiple gut functions: suppresses appetite (Y2R-mediated), slows gastric emptying, reduces intestinal motility, decreases pancreatic secretion, and promotes fluid absorption — PYY deficiency in obesity contributes to the disordered satiety driving overeating.
Why it matters
Relevant for neuropeptides, weight-loss.
How the study worked
review study on neuropeptides, weight-loss.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
The role of peptide YY in integrative gut physiology and potential role in obesity.
Current opinion in endocrinology, diabetes, and obesity, 14(1), 52-7
Citation
Grudell, April B M; Camilleri, Michael. (2007). The role of peptide YY in integrative gut physiology and potential role in obesity.. Current opinion in endocrinology, diabetes, and obesity, 14(1), 52-7.