Single-dose sitagliptin (DPP-4 inhibitor) did not modulate substance P-induced skin inflammation in healthy volunteers, despite DPP-4 degrading substance P — acute dosing may be insufficient for anti-inflammatory effects.
Key findingSingle-dose sitagliptin (DPP-4 inhibitor) did not modulate substance P-induced skin inflammation in healthy volunteers, despite DPP-4 degrading substa
What the researchers found
Single-dose sitagliptin (DPP-4 inhibitor) did not modulate substance P-induced skin inflammation in healthy volunteers, despite DPP-4 degrading substance P — acute dosing may be insufficient for anti-inflammatory effects.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2011.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
Common questions
What was studied?
What was found?
Read the original research
Substance P-induced skin inflammation is not modulated by a single dose of sitagliptin in human volunteers.
Biological chemistry, 392(3), 217-21
Citation
Grouzmann, Eric; Bigliardi, Paul; Appenzeller, Monique; Pannatier, André; Buclin, Thierry. (2011). Substance P-induced skin inflammation is not modulated by a single dose of sitagliptin in human volunteers.. Biological chemistry, 392(3), 217-21. https://doi.org/10.1515/BC.2011.003