Macrocyclic Melanocortin Agonists: New Ring-Shaped Peptides for Sexual Dysfunction and Beyond
Microwave-assisted synthesis produced novel macrocyclic peptides active at melanocortin MC1R/MC4R receptors, advancing circular peptide drug design for sexual dysfunction, tanning, and anti-inflammatory applications.
Quick Facts
What This Study Found
Novel macrocyclic melanocortin peptides synthesized by microwave-assisted methods showed potent MC1R/MC4R activity, with the macrocyclic constraint improving receptor selectivity and metabolic stability — advancing circular peptide drugs for melanocortin receptor-mediated therapies.
Key Numbers
How They Did This
in-vitro study.
Why This Research Matters
Relevant for melanotan, pt-141, peptide-design.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Novel macrocyclic melanocortin peptides synthesized by microwave-assisted methods showed potent MC1R/MC4R activity, with the macrocyclic constraint im
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists.
- Published In:
- Journal of medicinal chemistry, 51(9), 2701-7 (2008)
- Authors:
- Grieco, Paolo(2), Cai, Minying, Liu, Lu(2), Mayorov, Alexander, Chandler, Kevin, Trivedi, Dev, Lin, Guangxin, Campiglia, Pietro, Novellino, Ettore, Hruby, Victor J
- Database ID:
- RPEP-01346
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Macrocyclic Melanocortin Agonists: New Ring-Shaped Peptides for Sexual Dysfunction and Beyond
What was found?
Microwave-assisted synthesis produced novel macrocyclic peptides active at melanocortin MC1R/MC4R receptors, advancing circular peptide drug design for sexual dysfunction, tanning, and anti-inflammatory applications.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01346APA
Grieco, Paolo; Cai, Minying; Liu, Lu; Mayorov, Alexander; Chandler, Kevin; Trivedi, Dev; Lin, Guangxin; Campiglia, Pietro; Novellino, Ettore; Hruby, Victor J. (2008). Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists.. Journal of medicinal chemistry, 51(9), 2701-7. https://doi.org/10.1021/jm701181n
MLA
Grieco, Paolo, et al. "Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists.." Journal of medicinal chemistry, 2008. https://doi.org/10.1021/jm701181n
RethinkPeptides
RethinkPeptides Research Database. "Design and microwave-assisted synthesis of novel macrocyclic..." RPEP-01346. Retrieved from https://rethinkpeptides.com/research/grieco-2008-design-and-microwaveassisted-synthesis
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.