Cyclotide MCoTI-II Gets Inside Cells Through Macropinocytosis — Not Just Surface Binding
The macrocyclic peptide MCoTI-II was internalized into cells through macropinocytosis, demonstrating that cyclotides can enter cells and reach intracellular targets — critical for their drug scaffold potential.
Quick Facts
What This Study Found
MCoTI-II was internalized into human cells through macropinocytosis (not receptor-mediated endocytosis), accumulating in cytoplasm — demonstrating that macrocyclic peptide scaffolds can access intracellular targets, dramatically expanding their drug design utility.
Key Numbers
How They Did This
in-vitro study on cyclic-peptides, peptide-delivery.
Why This Research Matters
Relevant for cyclic-peptides, peptide-delivery, cell-penetrating.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding MCoTI-II was internalized into human cells through macropinocytosis (not receptor-mediated endocytosis), accumulating in cytoplasm — demonstrating tha
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2007.
- Original Title:
- The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.
- Published In:
- The international journal of biochemistry & cell biology, 39(12), 2252-64 (2007)
- Authors:
- Greenwood, Kathryn P, Daly, Norelle L(9), Brown, Darren L, Stow, Jennifer L, Craik, David J
- Database ID:
- RPEP-01235
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Cyclotide MCoTI-II Gets Inside Cells Through Macropinocytosis — Not Just Surface Binding
What was found?
The macrocyclic peptide MCoTI-II was internalized into cells through macropinocytosis, demonstrating that cyclotides can enter cells and reach intracellular targets — critical for their drug scaffold potential.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01235APA
Greenwood, Kathryn P; Daly, Norelle L; Brown, Darren L; Stow, Jennifer L; Craik, David J. (2007). The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.. The international journal of biochemistry & cell biology, 39(12), 2252-64.
MLA
Greenwood, Kathryn P, et al. "The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.." The international journal of biochemistry & cell biology, 2007.
RethinkPeptides
RethinkPeptides Research Database. "The cyclic cystine knot miniprotein MCoTI-II is internalized..." RPEP-01235. Retrieved from https://rethinkpeptides.com/research/greenwood-2007-the-cyclic-cystine-knot
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.