The macrocyclic peptide MCoTI-II was internalized into cells through macropinocytosis, demonstrating that cyclotides can enter cells and reach intracellular targets — critical for their drug scaffold potential.
Key findingMCoTI-II was internalized into human cells through macropinocytosis (not receptor-mediated endocytosis), accumulating in cytoplasm — demonstrating tha
What the researchers found
MCoTI-II was internalized into human cells through macropinocytosis (not receptor-mediated endocytosis), accumulating in cytoplasm — demonstrating that macrocyclic peptide scaffolds can access intracellular targets, dramatically expanding their drug design utility.
Why it matters
Relevant for cyclic-peptides, peptide-delivery, cell-penetrating.
How the study worked
in-vitro study on cyclic-peptides, peptide-delivery.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.
The international journal of biochemistry & cell biology, 39(12), 2252-64
Citation
Greenwood, Kathryn P; Daly, Norelle L; Brown, Darren L; Stow, Jennifer L; Craik, David J. (2007). The cyclic cystine knot miniprotein MCoTI-II is internalized into cells by macropinocytosis.. The international journal of biochemistry & cell biology, 39(12), 2252-64.