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Study breakdown

Insulin and GHRP-6 Both Help Diabetic Pituitary Cells But Through Different Mechanisms

evidence
The takeaway

Insulin and GHRP-6 had differential beneficial effects on pituitary cell turnover in diabetic rats: insulin through anti-apoptosis, GHRP-6 through proliferation — different mechanisms for restoring pituitary health.

Key finding

Insulin and GHRP-6 had differential beneficial effects on pituitary cell turnover in diabetic rats: insulin through anti-apoptosis, GHRP-6 through pro

What the researchers found

Insulin and GHRP-6 had differential beneficial effects on pituitary cell turnover in diabetic rats: insulin through anti-apoptosis, GHRP-6 through proliferation — different mechanisms for restoring pituitary health.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2011.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
Insulin and GHRP-6 Both Help Diabetic Pituitary Cells But Through Different Mechanisms
What was found?
Insulin and GHRP-6 had differential beneficial effects on pituitary cell turnover in diabetic rats: insulin through anti-apoptosis, GHRP-6 through proliferation — different mechanisms for restoring pituitary health.

Read the original research

Insulin and growth hormone-releasing peptide-6 (GHRP-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (STZ)-induced diabetic rats.

Molecular and cellular endocrinology, 337(1-2), 101-13

Citation

Granado, Miriam; García-Cáceres, Cristina; Tuda, María; Frago, Laura M; Chowen, Julie A; Argente, Jesús. (2011). Insulin and growth hormone-releasing peptide-6 (GHRP-6) have differential beneficial effects on cell turnover in the pituitary, hypothalamus and cerebellum of streptozotocin (STZ)-induced diabetic rats.. Molecular and cellular endocrinology, 337(1-2), 101-13. https://doi.org/10.1016/j.mce.2011.02.002