This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Postprandial increases in satiety gut hormones peptide YY (PYY), glucagon-like peptide-1 (GLP-1), and fibroblast growth factor-19 (FGF-19) after Roux-en-Y gastric bypass (RYGB) surgery reduce food reward and brain reward system activation. Acute suppression of these hormones with octreotide increased food reward behavior and brain responses in RYGB patients but not in controls.
Why it matters
Understanding how gut hormones influence food reward after gastric bypass can help develop new treatments for obesity that mimic surgery effects without invasive procedures. It highlights the hormonal control of appetite and food motivation.
How the study worked
Randomized, placebo-controlled, double-blind, crossover studies were conducted involving RYGB patients, gastric banding patients, and nonobese controls. Participants received octreotide or saline to suppress gut hormones, followed by behavioral food reward tasks and functional MRI to assess brain responses to food stimuli.
What this study cannot tell us
Small sample sizes limit generalizability, and the acute hormone suppression may not fully represent long-term effects. The study design cannot prove causality definitively.
Read the original research
Link Between Increased Satiety Gut Hormones and Reduced Food Reward After Gastric Bypass Surgery for Obesity.
The Journal of clinical endocrinology and metabolism, 101(2), 599-609
Citation
Goldstone, Anthony P; Miras, Alexander D; Scholtz, Samantha; Jackson, Sabrina; Neff, Karl J; Pénicaud, Luc; Geoghegan, Justin; Chhina, Navpreet; Durighel, Giuliana; Bell, Jimmy D; Meillon, Sophie; le Roux, Carel W. (2016). Link Between Increased Satiety Gut Hormones and Reduced Food Reward After Gastric Bypass Surgery for Obesity.. The Journal of clinical endocrinology and metabolism, 101(2), 599-609. https://doi.org/10.1210/jc.2015-2665