How RAMP Proteins Control Adrenomedullin Receptor Signaling
Receptor activity-modifying proteins (RAMPs) determine adrenomedullin receptor specificity and signaling, explaining how one receptor (CLR) is shared between adrenomedullin and CGRP with different RAMP partners.
Quick Facts
What This Study Found
RAMPs regulate adrenomedullin signaling by modifying calcitonin receptor-like receptor (CLR) specificity: RAMP2/RAMP3 create AM receptors, RAMP1 creates CGRP receptor — explaining how one receptor serves multiple peptide ligands through RAMP partnerships.
Key Numbers
How They Did This
review study on neuropeptides, receptor-signaling.
Why This Research Matters
Relevant for neuropeptides, receptor-signaling, cardiovascular.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding RAMPs regulate adrenomedullin signaling by modifying calcitonin receptor-like receptor (CLR) specificity: RAMP2/RAMP3 create AM receptors, RAMP1 creat
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling.
- Published In:
- Molecular endocrinology (Baltimore, Md.), 21(4), 783-96 (2007)
- Database ID:
- RPEP-01232
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
How RAMP Proteins Control Adrenomedullin Receptor Signaling
What was found?
Receptor activity-modifying proteins (RAMPs) determine adrenomedullin receptor specificity and signaling, explaining how one receptor (CLR) is shared between adrenomedullin and CGRP with different RAMP partners.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-01232APA
Gibbons, Carrie; Dackor, Ryan; Dunworth, William; Fritz-Six, Kimberly; Caron, Kathleen M. (2007). Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling.. Molecular endocrinology (Baltimore, Md.), 21(4), 783-96.
MLA
Gibbons, Carrie, et al. "Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling.." Molecular endocrinology (Baltimore, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Receptor activity-modifying proteins: RAMPing up adrenomedul..." RPEP-01232. Retrieved from https://rethinkpeptides.com/research/gibbons-2007-receptor-activitymodifying-proteins-ramping
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.