Receptor activity-modifying proteins (RAMPs) determine adrenomedullin receptor specificity and signaling, explaining how one receptor (CLR) is shared between adrenomedullin and CGRP with different RAMP partners.
Key findingRAMPs regulate adrenomedullin signaling by modifying calcitonin receptor-like receptor (CLR) specificity: RAMP2/RAMP3 create AM receptors, RAMP1 creat
What the researchers found
RAMPs regulate adrenomedullin signaling by modifying calcitonin receptor-like receptor (CLR) specificity: RAMP2/RAMP3 create AM receptors, RAMP1 creates CGRP receptor — explaining how one receptor serves multiple peptide ligands through RAMP partnerships.
Why it matters
Relevant for neuropeptides, receptor-signaling, cardiovascular.
How the study worked
review study on neuropeptides, receptor-signaling.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling.
Molecular endocrinology (Baltimore, Md.), 21(4), 783-96
Citation
Gibbons, Carrie; Dackor, Ryan; Dunworth, William; Fritz-Six, Kimberly; Caron, Kathleen M. (2007). Receptor activity-modifying proteins: RAMPing up adrenomedullin signaling.. Molecular endocrinology (Baltimore, Md.), 21(4), 783-96.