Growth differentiation factor 15 (GDF15) and semaglutide inhibit food intake and body weight through largely distinct, additive mechanisms.
Quick Facts
What This Study Found
Combined treatment with GDF15 and semaglutide resulted in greater weight loss and food intake suppression compared to either treatment alone.
Key Numbers
How They Did This
The study used rat experiments to assess the effects of GDF15 and semaglutide on food intake and weight loss through various behavioral and neural mechanisms.
Why This Research Matters
Understanding how these treatments work can lead to more effective obesity therapies. The distinct mechanisms suggest potential for combination therapies in weight management.
What This Study Doesn't Tell Us
The study was conducted in rats, and results may not directly translate to humans.
Trust & Context
- Original Title:
- Growth differentiation factor 15 (GDF15) and semaglutide inhibit food intake and body weight through largely distinct, additive mechanisms.
- Published In:
- Diabetes, obesity & metabolism, 24(6), 1010-1020 (2022)
- Authors:
- Ghidewon, M, Wald, H S, McKnight, A D, De Jonghe, B C, Breen, D M, Alhadeff, A L, Borner, T, Grill, H J
- Database ID:
- RPEP-06135
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06135APA
Ghidewon, M; Wald, H S; McKnight, A D; De Jonghe, B C; Breen, D M; Alhadeff, A L; Borner, T; Grill, H J. (2022). Growth differentiation factor 15 (GDF15) and semaglutide inhibit food intake and body weight through largely distinct, additive mechanisms.. Diabetes, obesity & metabolism, 24(6), 1010-1020. https://doi.org/10.1111/dom.14663
MLA
Ghidewon, M, et al. "Growth differentiation factor 15 (GDF15) and semaglutide inhibit food intake and body weight through largely distinct, additive mechanisms.." Diabetes, 2022. https://doi.org/10.1111/dom.14663
RethinkPeptides
RethinkPeptides Research Database. "Growth differentiation factor 15 (GDF15) and semaglutide inh..." RPEP-06135. Retrieved from https://rethinkpeptides.com/research/ghidewon-2022-growth-differentiation-factor-15
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.