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Study breakdown

Gut Sweet Taste Receptors Control GLP-1, PYY, and CCK Release in Humans

evidence
The takeaway

Sweet taste receptors in the human gut regulated GLP-1, PYY, and CCK release in response to intragastric glucose, with blocking sweet taste reducing satiety hormone output — taste receptors as gut hormone triggers.

Key finding

Sweet taste receptors in the human gut regulated GLP-1, PYY, and CCK release in response to intragastric glucose, with blocking sweet taste reducing s

What the researchers found

Sweet taste receptors in the human gut regulated GLP-1, PYY, and CCK release in response to intragastric glucose, with blocking sweet taste reducing satiety hormone output — taste receptors as gut hormone triggers.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2011.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
Gut Sweet Taste Receptors Control GLP-1, PYY, and CCK Release in Humans
What was found?
Sweet taste receptors in the human gut regulated GLP-1, PYY, and CCK release in response to intragastric glucose, with blocking sweet taste reducing satiety hormone output — taste receptors as gut hormone triggers.

Read the original research

The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans.

American journal of physiology. Endocrinology and metabolism, 301(2), E317-25

Citation

Gerspach, A C; Steinert, R E; Schönenberger, L; Graber-Maier, A; Beglinger, C. (2011). The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans.. American journal of physiology. Endocrinology and metabolism, 301(2), E317-25. https://doi.org/10.1152/ajpendo.00077.2011