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Study breakdown

Intact Dietary Proteins Directly Trigger CCK and GLP-1 Release From Gut Hormone Cells

evidence
The takeaway

Intact (not just digested) dietary proteins directly stimulated CCK and GLP-1 release from murine enteroendocrine cells, demonstrating that protein sensing in the gut begins before complete digestion.

Key finding

Intact (not just digested) dietary proteins directly stimulated CCK and GLP-1 release from murine enteroendocrine cells, demonstrating that protein se

What the researchers found

Intact (not just digested) dietary proteins directly stimulated CCK and GLP-1 release from murine enteroendocrine cells, demonstrating that protein sensing in the gut begins before complete digestion.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2011.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
Intact Dietary Proteins Directly Trigger CCK and GLP-1 Release From Gut Hormone Cells
What was found?
Intact (not just digested) dietary proteins directly stimulated CCK and GLP-1 release from murine enteroendocrine cells, demonstrating that protein sensing in the gut begins before complete digestion.

Read the original research

Direct induction of CCK and GLP-1 release from murine endocrine cells by intact dietary proteins.

Molecular nutrition & food research, 55(3), 476-84

Citation

Geraedts, Maartje C P; Troost, Freddy J; Fischer, Marc A J G; Edens, Luppo; Saris, Wim H M. (2011). Direct induction of CCK and GLP-1 release from murine endocrine cells by intact dietary proteins.. Molecular nutrition & food research, 55(3), 476-84. https://doi.org/10.1002/mnfr.201000142