Surprise: Des-Acyl Ghrelin Is Actually a Full Agonist at the Ghrelin Receptor, Not Inactive
Unacylated (des-acyl) ghrelin unexpectedly functioned as a full agonist at the GHS-R1a receptor (previously thought to be inactive at this receptor), challenging the assumption that only acylated ghrelin has GHS-R activity.
Quick Facts
What This Study Found
Des-acyl ghrelin, previously considered inactive at GHS-R1a, demonstrated full agonist activity at the type 1a receptor — challenging the fundamental assumption that only acylated ghrelin has GHS-R activity and redefining des-acyl ghrelin's biological role.
Key Numbers
How They Did This
in-vitro study on ghrp, receptor-signaling.
Why This Research Matters
Relevant for ghrp, receptor-signaling.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Des-acyl ghrelin, previously considered inactive at GHS-R1a, demonstrated full agonist activity at the type 1a receptor — challenging the fundamental
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R).
- Published In:
- Molecular and cellular endocrinology, 274(1-2), 30-4 (2007)
- Authors:
- Gauna, Carlotta, van de Zande, Bedette, van Kerkwijk, Anke, Themmen, Axel P N, van der Lely, A J, Delhanty, Patric J D
- Database ID:
- RPEP-01229
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Surprise: Des-Acyl Ghrelin Is Actually a Full Agonist at the Ghrelin Receptor, Not Inactive
What was found?
Unacylated (des-acyl) ghrelin unexpectedly functioned as a full agonist at the GHS-R1a receptor (previously thought to be inactive at this receptor), challenging the assumption that only acylated ghrelin has GHS-R activity.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01229APA
Gauna, Carlotta; van de Zande, Bedette; van Kerkwijk, Anke; Themmen, Axel P N; van der Lely, A J; Delhanty, Patric J D. (2007). Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R).. Molecular and cellular endocrinology, 274(1-2), 30-4.
MLA
Gauna, Carlotta, et al. "Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R).." Molecular and cellular endocrinology, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Unacylated ghrelin is not a functional antagonist but a full..." RPEP-01229. Retrieved from https://rethinkpeptides.com/research/gauna-2007-unacylated-ghrelin-is-not
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.