Unacylated (des-acyl) ghrelin unexpectedly functioned as a full agonist at the GHS-R1a receptor (previously thought to be inactive at this receptor), challenging the assumption that only acylated ghrelin has GHS-R activity.
Key findingDes-acyl ghrelin, previously considered inactive at GHS-R1a, demonstrated full agonist activity at the type 1a receptor — challenging the fundamental
What the researchers found
Des-acyl ghrelin, previously considered inactive at GHS-R1a, demonstrated full agonist activity at the type 1a receptor — challenging the fundamental assumption that only acylated ghrelin has GHS-R activity and redefining des-acyl ghrelin's biological role.
Why it matters
Relevant for ghrp, receptor-signaling.
How the study worked
in-vitro study on ghrp, receptor-signaling.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R).
Molecular and cellular endocrinology, 274(1-2), 30-4
Citation
Gauna, Carlotta; van de Zande, Bedette; van Kerkwijk, Anke; Themmen, Axel P N; van der Lely, A J; Delhanty, Patric J D. (2007). Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R).. Molecular and cellular endocrinology, 274(1-2), 30-4.