Bovine lactoferricin's anticancer activity against leukemia was enhanced by modulating ceramide metabolism, identifying the ceramide-mediated apoptotic pathway as the mechanism for peptide-induced cancer cell death.
Key findingLactoferricin B induced leukemia cell apoptosis through ceramide accumulation, and modulating ceramide metabolism (glucocerebrosidase inhibition) pote
What the researchers found
Lactoferricin B induced leukemia cell apoptosis through ceramide accumulation, and modulating ceramide metabolism (glucocerebrosidase inhibition) potentiated the killing — identifying the ceramide death pathway as the molecular mechanism for this anticancer peptide.
Why it matters
Relevant for antimicrobial-peptides, cancer.
How the study worked
in-vitro study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin.
International journal of oncology, 32(3), 537-44
Citation
Furlong, Suzanne J; Ridgway, Neale D; Hoskin, David W. (2008). Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin.. International journal of oncology, 32(3), 537-44.