Spinal Cord Stimulation Releases Opioid Peptides in Patients With Limb Ischemia
Long-term spinal cord stimulation in patients with critical limb ischemia increased cerebrospinal fluid beta-endorphin levels, providing an opioid mechanism for the pain relief and improved blood flow from this treatment.
Quick Facts
What This Study Found
Spinal cord stimulation in chronic critical limb ischemia patients increased CSF beta-endorphin levels, correlating with improved microvascular flow and wound healing — an endogenous opioid mechanism for SCS therapeutic effects.
Key Numbers
How They Did This
clinical-trial study. Details in abstract.
Why This Research Matters
Advances understanding in opioid-peptides, pain, clinical-trials research.
The Bigger Picture
Contributes to the growing body of evidence in peptide research.
What This Study Doesn't Tell Us
See abstract for study-specific limitations.
Questions This Raises
- ?Further research needed to confirm and extend findings.
- ?Clinical translation potential to be evaluated.
Trust & Context
- Key Stat:
- Key finding Spinal cord stimulation in chronic critical limb ischemia patients increased CSF beta-endorphin levels, correlating with improved microvascular flow a
- Evidence Grade:
- preliminary evidence from clinical-trial study.
- Study Age:
- Published in 2004.
- Original Title:
- Opioid peptide response to spinal cord stimulation in chronic critical limb ischemia.
- Published In:
- Peptides, 25(4), 571-5 (2004)
- Authors:
- Fontana, Fiorella(2), Bernardi, Pasquale(2), Lanfranchi, Giuseppina, Spampinato, Santi, Di Toro, Rosanna, Conti, Eleonora, Bonafè, Francesca, Coccheri, Sergio
- Database ID:
- RPEP-00914
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Spinal Cord Stimulation Releases Opioid Peptides in Patients With Limb Ischemia
What was found?
Long-term spinal cord stimulation in patients with critical limb ischemia increased cerebrospinal fluid beta-endorphin levels, providing an opioid mechanism for the pain relief and improved blood flow from this treatment.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00914APA
Fontana, Fiorella; Bernardi, Pasquale; Lanfranchi, Giuseppina; Spampinato, Santi; Di Toro, Rosanna; Conti, Eleonora; Bonafè, Francesca; Coccheri, Sergio. (2004). Opioid peptide response to spinal cord stimulation in chronic critical limb ischemia.. Peptides, 25(4), 571-5.
MLA
Fontana, Fiorella, et al. "Opioid peptide response to spinal cord stimulation in chronic critical limb ischemia.." Peptides, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Opioid peptide response to spinal cord stimulation in chroni..." RPEP-00914. Retrieved from https://rethinkpeptides.com/research/fontana-2004-opioid-peptide-response-to
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.