A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines.
Quick Facts
What This Study Found
The study identified six peptide candidates that successfully controlled tumors in mice.
Key Numbers
How They Did This
The researchers used immunoprecipitation and mass spectrometry to isolate peptides, followed by RNAseq analysis and functional assays to select the best candidates.
Why This Research Matters
This research addresses key challenges in cancer vaccine development, potentially leading to more effective treatments for patients. It sets the stage for future human trials.
What This Study Doesn't Tell Us
The study was conducted in a murine model, and results may not directly translate to humans. Further validation in clinical settings is needed.
Trust & Context
- Original Title:
- A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines.
- Published In:
- eLife, 11 (2022)
- Authors:
- Feola, Sara, Chiaro, Jacopo, Martins, Beatriz, Russo, Salvatore, Fusciello, Manlio, Ylösmäki, Erkko, Bonini, Chiara, Ruggiero, Eliana, Hamdan, Firas, Feodoroff, Michaela, Antignani, Gabriella, Viitala, Tapani, Pesonen, Sari, Grönholm, Mikaela, Branca, Rui M M, Lehtiö, Janne, Cerullo, Vincenzo
- Database ID:
- RPEP-06120
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06120APA
Feola, Sara; Chiaro, Jacopo; Martins, Beatriz; Russo, Salvatore; Fusciello, Manlio; Ylösmäki, Erkko; Bonini, Chiara; Ruggiero, Eliana; Hamdan, Firas; Feodoroff, Michaela; Antignani, Gabriella; Viitala, Tapani; Pesonen, Sari; Grönholm, Mikaela; Branca, Rui M M; Lehtiö, Janne; Cerullo, Vincenzo. (2022). A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines.. eLife, 11. https://doi.org/10.7554/eLife.71156
MLA
Feola, Sara, et al. "A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines.." eLife, 2022. https://doi.org/10.7554/eLife.71156
RethinkPeptides
RethinkPeptides Research Database. "A novel immunopeptidomic-based pipeline for the generation o..." RPEP-06120. Retrieved from https://rethinkpeptides.com/research/feola-2022-a-novel-immunopeptidomicbased-pipeline
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.