This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Starved ghrelin-deficient mice had a 90% reduction in plasma IGF-1 compared to wild-type mice.
Why it matters
Understanding how IGF-1 functions during starvation could inform treatments for metabolic disorders and improve our knowledge of energy regulation.
How the study worked
The study involved comparing wild-type mice and ghrelin-deficient mice under starvation conditions, measuring plasma IGF-1 levels and glucose production.
What this study cannot tell us
The study was conducted in mice, and results may not directly translate to humans.
Read the original research
Unexpected role for IGF-1 in starvation: Maintenance of blood glucose.
Proceedings of the National Academy of Sciences of the United States of America, 119(32), e2208855119
Citation
Fang, Fei; Goldstein, Joseph L; Shi, Xuanming; Liang, Guosheng; Brown, Michael S. (2022). Unexpected role for IGF-1 in starvation: Maintenance of blood glucose.. Proceedings of the National Academy of Sciences of the United States of America, 119(32), e2208855119. https://doi.org/10.1073/pnas.2208855119