Detailed mapping of enkephalin, dynorphin, and endorphin distribution in the rostral agranular insular cortex — a brain region processing pain's emotional component — revealed distinct opioid peptide laminar organization.
Key findingImmunohistochemical mapping revealed distinct laminar distributions of met-enkephalin, dynorphin, and beta-endorphin in the rostral agranular insular
What the researchers found
Immunohistochemical mapping revealed distinct laminar distributions of met-enkephalin, dynorphin, and beta-endorphin in the rostral agranular insular cortex — the brain's emotional pain processing region — providing the opioid peptide architecture for pain affect modulation.
Why it matters
Relevant for opioid-peptides, neuropeptides, pain.
How the study worked
animal-study study on opioid-peptides, neuropeptides.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Organization of endogenous opioids in the rostral agranular insular cortex of the rat.
The Journal of comparative neurology, 500(3), 530-41
Citation
Evans, Joshua M; Bey, Vincent; Burkey, Adam R; Commons, Kathryn G. (2007). Organization of endogenous opioids in the rostral agranular insular cortex of the rat.. The Journal of comparative neurology, 500(3), 530-41.