The ghrelin receptor's constitutive activity (always partially active) can be blocked by inverse agonists, which reduce the receptor's baseline signaling — a more effective obesity strategy than simple antagonism.
Key findingThe ghrelin receptor's constitutive activity (always partially active) can be blocked by inverse agonists, which reduce the receptor's baseline signal
What the researchers found
The ghrelin receptor's constitutive activity (always partially active) can be blocked by inverse agonists, which reduce the receptor's baseline signaling — a more effective obesity strategy than simple antagonism.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2010.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
Common questions
What was studied?
What was found?
Read the original research
Ghrelin receptor: high constitutive activity and methods for developing inverse agonists.
Methods in enzymology, 485, 103-21
Citation
Els, Sylvia; Beck-Sickinger, Annette G; Chollet, Constance. (2010). Ghrelin receptor: high constitutive activity and methods for developing inverse agonists.. Methods in enzymology, 485, 103-21. https://doi.org/10.1016/B978-0-12-381296-4.00006-3