Bovine lactoferricin B was cytotoxic to neuroblastoma cells in vitro and significantly inhibited xenograft tumor growth in vivo in mice — the first in-vivo evidence for lactoferricin's anticancer activity against a solid tumor.
Key findingLactoferricin B killed neuroblastoma cells in culture and significantly reduced xenograft tumor growth in nude mice — the first in-vivo demonstration
What the researchers found
Lactoferricin B killed neuroblastoma cells in culture and significantly reduced xenograft tumor growth in nude mice — the first in-vivo demonstration of lactoferricin anticancer efficacy against a pediatric solid tumor.
Why it matters
Relevant for antimicrobial-peptides, cancer.
How the study worked
animal-study study on antimicrobial-peptides, cancer.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo.
International journal of cancer, 119(3), 493-500
Citation
Eliassen, Liv Tone; Berge, Gerd; Leknessund, Arild; Wikman, Mari; Lindin, Inger; Løkke, Cecilie; Ponthan, Frida; Johnsen, John Inge; Sveinbjørnsson, Baldur; Kogner, Per; Flaegstad, Trond; Rekdal, Øystein. (2006). The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo.. International journal of cancer, 119(3), 493-500.