Chronic ghrelin and GHRP exposure upregulated high-voltage calcium channels in pituitary somatotrophs, increasing GH secretory capacity — explaining how sustained GH secretagogue treatment may enhance rather than desensitize pituitary GH release.
Key findingChronic ghrelin/GHRP exposure upregulated L-type and T-type high-voltage calcium channels in GC somatotrophs, enhancing calcium-dependent GH exocytosi
What the researchers found
Chronic ghrelin/GHRP exposure upregulated L-type and T-type high-voltage calcium channels in GC somatotrophs, enhancing calcium-dependent GH exocytosis capacity — a mechanism for sustained or increasing GH response during chronic secretagogue treatment.
Why it matters
Relevant for ghrp, receptor-signaling.
How the study worked
in-vitro study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Up-regulation of high voltage-activated Ca(2+) channels in GC somatotropes after long-term exposure to ghrelin and growth hormone releasing peptide-6.
Cellular and molecular neurobiology, 28(6), 819-31
Citation
Dominguez, Belisario; Avila, Traudy; Flores-Hernandez, Jorge; Lopez-Lopez, Gustavo; Martinez-Rodriguez, Herminia; Felix, Ricardo; Monjaraz, Eduardo. (2008). Up-regulation of high voltage-activated Ca(2+) channels in GC somatotropes after long-term exposure to ghrelin and growth hormone releasing peptide-6.. Cellular and molecular neurobiology, 28(6), 819-31. https://doi.org/10.1007/s10571-007-9234-1