Elucidating the Impact of Payload Conjugation on the Cell-Penetrating Efficiency of the Endosomal Escape Peptide dfTAT: Implications for Future Designs for CPP-Based Delivery Systems.
Quick Facts
What This Study Found
Larger payloads reduce dfTAT's endocytic uptake and endosomal escape efficiency.
Key Numbers
How They Did This
The study systematically examined the effects of various payload sizes on the cell-penetrating activity of the dfTAT peptide.
Why This Research Matters
Understanding how payload size impacts peptide delivery can lead to improved drug delivery systems. This knowledge is crucial for developing therapies that rely on cell-penetrating peptides.
What This Study Doesn't Tell Us
The study primarily focuses on one peptide and may not generalize to all cell-penetrating peptides or payloads.
Trust & Context
- Original Title:
- Elucidating the Impact of Payload Conjugation on the Cell-Penetrating Efficiency of the Endosomal Escape Peptide dfTAT: Implications for Future Designs for CPP-Based Delivery Systems.
- Published In:
- Bioconjugate chemistry, 34(10), 1861-1872 (2023)
- Authors:
- Diaz, Joshua, Pietsch, Miles, Davila, Marissa, Jaimes, Gerardo, Hudson, Alexis, Pellois, Jean-Philippe
- Database ID:
- RPEP-06839
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06839APA
Diaz, Joshua; Pietsch, Miles; Davila, Marissa; Jaimes, Gerardo; Hudson, Alexis; Pellois, Jean-Philippe. (2023). Elucidating the Impact of Payload Conjugation on the Cell-Penetrating Efficiency of the Endosomal Escape Peptide dfTAT: Implications for Future Designs for CPP-Based Delivery Systems.. Bioconjugate chemistry, 34(10), 1861-1872. https://doi.org/10.1021/acs.bioconjchem.3c00369
MLA
Diaz, Joshua, et al. "Elucidating the Impact of Payload Conjugation on the Cell-Penetrating Efficiency of the Endosomal Escape Peptide dfTAT: Implications for Future Designs for CPP-Based Delivery Systems.." Bioconjugate chemistry, 2023. https://doi.org/10.1021/acs.bioconjchem.3c00369
RethinkPeptides
RethinkPeptides Research Database. "Elucidating the Impact of Payload Conjugation on the Cell-Pe..." RPEP-06839. Retrieved from https://rethinkpeptides.com/research/diaz-2023-elucidating-the-impact-of
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.