Ghrelin, GHRP-6, and motilin were compared for gastroprokinetic effects, with ghrelin and GHRP-6 stimulating gastric motility through both GHS-R and motilin receptor cross-activation — confirming dual receptor engagement for gut effects.
Key findingGhrelin and GHRP-6 stimulated gastric motility in rats through both GHS-R and motilin receptor cross-activation, with efficacy comparable to motilin —
What the researchers found
Ghrelin and GHRP-6 stimulated gastric motility in rats through both GHS-R and motilin receptor cross-activation, with efficacy comparable to motilin — confirming the bidirectional receptor overlap drives GH secretagogue gut motility effects.
Why it matters
Relevant for ghrp, gut-healing, receptor-signaling.
How the study worked
animal-study study on ghrp, gut-healing.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro.
European journal of pharmacology, 515(1-3), 160-8
Citation
Depoortere, Inge; De Winter, Benedicte; Thijs, Theo; De Man, Joris; Pelckmans, Paul; Peeters, Theo. (2005). Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro.. European journal of pharmacology, 515(1-3), 160-8.