Ghrelin, GHRP-6, and Motilin: Comparing Their Gut Motility Effects Head-to-Head
Ghrelin, GHRP-6, and motilin were compared for gastroprokinetic effects, with ghrelin and GHRP-6 stimulating gastric motility through both GHS-R and motilin receptor cross-activation — confirming dual receptor engagement for gut effects.
Quick Facts
What This Study Found
Ghrelin and GHRP-6 stimulated gastric motility in rats through both GHS-R and motilin receptor cross-activation, with efficacy comparable to motilin — confirming the bidirectional receptor overlap drives GH secretagogue gut motility effects.
Key Numbers
How They Did This
animal-study study on ghrp, gut-healing.
Why This Research Matters
Relevant for ghrp, gut-healing, receptor-signaling.
The Bigger Picture
Advances peptide research with clinical implications.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Ghrelin and GHRP-6 stimulated gastric motility in rats through both GHS-R and motilin receptor cross-activation, with efficacy comparable to motilin —
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2005.
- Original Title:
- Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro.
- Published In:
- European journal of pharmacology, 515(1-3), 160-8 (2005)
- Authors:
- Depoortere, Inge(4), De Winter, Benedicte, Thijs, Theo(3), De Man, Joris, Pelckmans, Paul, Peeters, Theo
- Database ID:
- RPEP-01026
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Ghrelin, GHRP-6, and Motilin: Comparing Their Gut Motility Effects Head-to-Head
What was found?
Ghrelin, GHRP-6, and motilin were compared for gastroprokinetic effects, with ghrelin and GHRP-6 stimulating gastric motility through both GHS-R and motilin receptor cross-activation — confirming dual receptor engagement for gut effects.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-01026APA
Depoortere, Inge; De Winter, Benedicte; Thijs, Theo; De Man, Joris; Pelckmans, Paul; Peeters, Theo. (2005). Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro.. European journal of pharmacology, 515(1-3), 160-8.
MLA
Depoortere, Inge, et al. "Comparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitro.." European journal of pharmacology, 2005.
RethinkPeptides
RethinkPeptides Research Database. "Comparison of the gastroprokinetic effects of ghrelin, GHRP-..." RPEP-01026. Retrieved from https://rethinkpeptides.com/research/depoortere-2005-comparison-of-the-gastroprokinetic
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.