Palmitate-Induced Inflammation and Myotube Atrophy in C2C12 Cells Are Prevented by the Whey Bioactive Peptide, Glycomacropeptide.
Quick Facts
What This Study Found
GMP prevented palmitate-induced decrease in myotube area and increased inflammatory gene expression after 24 hours.
Key Numbers
How They Did This
C2C12 myoblasts were differentiated and treated with palmitate and GMP to assess effects on muscle atrophy and inflammation over 6-24 hours.
Why This Research Matters
Understanding how GMP protects muscle cells could lead to new treatments for muscle atrophy associated with metabolic diseases. This research highlights the potential of dietary peptides in managing inflammation and muscle health.
What This Study Doesn't Tell Us
The study was conducted in vitro using C2C12 cells, which may not fully replicate human muscle responses.
Trust & Context
- Original Title:
- Palmitate-Induced Inflammation and Myotube Atrophy in C2C12 Cells Are Prevented by the Whey Bioactive Peptide, Glycomacropeptide.
- Published In:
- The Journal of nutrition, 153(10), 2915-2928 (2023)
- Authors:
- de Hart, Naomi Mmp, Petrocelli, Jonathan J, Nicholson, Rebekah J, Yee, Elena M, Ferrara, Patrick J, Bastian, Eric D, Ward, Loren S, Petersen, Brent L, Summers, Scott A, Drummond, Micah J
- Database ID:
- RPEP-06827
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06827APA
de Hart, Naomi Mmp; Petrocelli, Jonathan J; Nicholson, Rebekah J; Yee, Elena M; Ferrara, Patrick J; Bastian, Eric D; Ward, Loren S; Petersen, Brent L; Summers, Scott A; Drummond, Micah J. (2023). Palmitate-Induced Inflammation and Myotube Atrophy in C2C12 Cells Are Prevented by the Whey Bioactive Peptide, Glycomacropeptide.. The Journal of nutrition, 153(10), 2915-2928. https://doi.org/10.1016/j.tjnut.2023.08.033
MLA
de Hart, Naomi Mmp, et al. "Palmitate-Induced Inflammation and Myotube Atrophy in C2C12 Cells Are Prevented by the Whey Bioactive Peptide, Glycomacropeptide.." The Journal of nutrition, 2023. https://doi.org/10.1016/j.tjnut.2023.08.033
RethinkPeptides
RethinkPeptides Research Database. "Palmitate-Induced Inflammation and Myotube Atrophy in C2C12 ..." RPEP-06827. Retrieved from https://rethinkpeptides.com/research/de-2023-palmitateinduced-inflammation-and-myotube
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.