This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
GMP prevented palmitate-induced decrease in myotube area and increased inflammatory gene expression after 24 hours.
Why it matters
Understanding how GMP protects muscle cells could lead to new treatments for muscle atrophy associated with metabolic diseases. This research highlights the potential of dietary peptides in managing inflammation and muscle health.
How the study worked
C2C12 myoblasts were differentiated and treated with palmitate and GMP to assess effects on muscle atrophy and inflammation over 6-24 hours.
What this study cannot tell us
The study was conducted in vitro using C2C12 cells, which may not fully replicate human muscle responses.
Read the original research
Palmitate-Induced Inflammation and Myotube Atrophy in C2C12 Cells Are Prevented by the Whey Bioactive Peptide, Glycomacropeptide.
The Journal of nutrition, 153(10), 2915-2928
Citation
de Hart, Naomi Mmp; Petrocelli, Jonathan J; Nicholson, Rebekah J; Yee, Elena M; Ferrara, Patrick J; Bastian, Eric D; Ward, Loren S; Petersen, Brent L; Summers, Scott A; Drummond, Micah J. (2023). Palmitate-Induced Inflammation and Myotube Atrophy in C2C12 Cells Are Prevented by the Whey Bioactive Peptide, Glycomacropeptide.. The Journal of nutrition, 153(10), 2915-2928. https://doi.org/10.1016/j.tjnut.2023.08.033