Mucosal immune alterations at the early onset of tissue destruction in chronic obstructive pulmonary disease.
Quick Facts
What This Study Found
In mildly affected COPD zones, decreased defensins and increased mucus were observed alongside CD8+ T cell accumulation.
Key Numbers
How They Did This
The study analyzed lung tissue from 11 healthy controls and 11 end-stage COPD patients using microCT and RNA transcriptomic analysis.
Why This Research Matters
Understanding early immune changes in COPD can help in developing targeted therapies. It highlights the potential for early intervention before severe lung damage occurs.
What This Study Doesn't Tell Us
The study is limited by its small sample size and focus on end-stage COPD, which may not represent earlier disease stages.
Trust & Context
- Original Title:
- Mucosal immune alterations at the early onset of tissue destruction in chronic obstructive pulmonary disease.
- Published In:
- Frontiers in immunology, 14, 1275845 (2023)
- Authors:
- de Fays, Charlotte, Geudens, Vincent, Gyselinck, Iwein, Kerckhof, Pieterjan, Vermaut, Astrid, Goos, Tinne, Vermant, Marie, Beeckmans, Hanne, Kaes, Janne, Van Slambrouck, Jan, Mohamady, Yousry, Willems, Lynn, Aversa, Lucia, Cortesi, Emanuela E, Hooft, Charlotte, Aerts, Gitte, Aelbrecht, Celine, Everaerts, Stephanie, McDonough, John E, De Sadeleer, Laurens J, Gohy, Sophie, Ambroise, Jerome, Janssens, Wim, Ceulemans, Laurens J, Van Raemdonck, Dirk, Vos, Robin, Hackett, Tillie L, Hogg, James C, Kaminski, Naftali, Gayan-Ramirez, Ghislaine, Pilette, Charles, Vanaudenaerde, Bart M
- Database ID:
- RPEP-06826
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06826APA
de Fays, Charlotte; Geudens, Vincent; Gyselinck, Iwein; Kerckhof, Pieterjan; Vermaut, Astrid; Goos, Tinne; Vermant, Marie; Beeckmans, Hanne; Kaes, Janne; Van Slambrouck, Jan; Mohamady, Yousry; Willems, Lynn; Aversa, Lucia; Cortesi, Emanuela E; Hooft, Charlotte; Aerts, Gitte; Aelbrecht, Celine; Everaerts, Stephanie; McDonough, John E; De Sadeleer, Laurens J; Gohy, Sophie; Ambroise, Jerome; Janssens, Wim; Ceulemans, Laurens J; Van Raemdonck, Dirk; Vos, Robin; Hackett, Tillie L; Hogg, James C; Kaminski, Naftali; Gayan-Ramirez, Ghislaine; Pilette, Charles; Vanaudenaerde, Bart M. (2023). Mucosal immune alterations at the early onset of tissue destruction in chronic obstructive pulmonary disease.. Frontiers in immunology, 14, 1275845. https://doi.org/10.3389/fimmu.2023.1275845
MLA
de Fays, Charlotte, et al. "Mucosal immune alterations at the early onset of tissue destruction in chronic obstructive pulmonary disease.." Frontiers in immunology, 2023. https://doi.org/10.3389/fimmu.2023.1275845
RethinkPeptides
RethinkPeptides Research Database. "Mucosal immune alterations at the early onset of tissue dest..." RPEP-06826. Retrieved from https://rethinkpeptides.com/research/de-2023-mucosal-immune-alterations-at
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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.