Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake.
Quick Facts
What This Study Found
Rigidifying the macrocycle improved alpha helicity, target affinity, and proteolytic stability.
Key Numbers
How They Did This
The study systematically compared various cyclization constraints and linker positions to assess their effects on peptide properties.
Why This Research Matters
Enhancing the delivery and stability of peptides could lead to more effective cancer therapies. This research provides insights into designing better therapeutic peptides.
What This Study Doesn't Tell Us
The study primarily focuses on in vitro conditions, which may not fully replicate in vivo environments.
Trust & Context
- Original Title:
- Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake.
- Published In:
- RSC chemical biology, 3(7), 895-904 (2022)
- Authors:
- de Araujo, Aline D, Lim, Junxian, Wu, Kai-Chen, Hoang, Huy N, Nguyen, Huy T, Fairlie, David P
- Database ID:
- RPEP-06078
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06078APA
de Araujo, Aline D; Lim, Junxian; Wu, Kai-Chen; Hoang, Huy N; Nguyen, Huy T; Fairlie, David P. (2022). Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake.. RSC chemical biology, 3(7), 895-904. https://doi.org/10.1039/d1cb00231g
MLA
de Araujo, Aline D, et al. "Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake.." RSC chemical biology, 2022. https://doi.org/10.1039/d1cb00231g
RethinkPeptides
RethinkPeptides Research Database. "Landscaping macrocyclic peptides: stapling hDM2-binding pept..." RPEP-06078. Retrieved from https://rethinkpeptides.com/research/de-2022-landscaping-macrocyclic-peptides-stapling
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.