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Motilin and Ghrelin as Prokinetic Drug Targets for Gastroparesis and GI Motility Disorders

evidence
The takeaway

Motilin and ghrelin receptor agonists are prokinetic drug candidates for gastroparesis, with ghrelin's dual appetite + motility effects offering unique therapeutic advantages over pure prokinetics.

Key finding

Motilin and ghrelin receptor agonists are prokinetic drug candidates for gastroparesis, with ghrelin's dual appetite + motility effects offering uniqu

What the researchers found

Motilin and ghrelin receptor agonists are prokinetic drug candidates for gastroparesis, with ghrelin's dual appetite + motility effects offering unique therapeutic advantages over pure prokinetics.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2009.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
Motilin and Ghrelin as Prokinetic Drug Targets for Gastroparesis and GI Motility Disorders
What was found?
Motilin and ghrelin receptor agonists are prokinetic drug candidates for gastroparesis, with ghrelin's dual appetite + motility effects offering unique therapeutic advantages over pure prokinetics.

Read the original research

Motilin and ghrelin as prokinetic drug targets.

Pharmacology & therapeutics, 123(2), 207-23

Citation

De Smet, Betty; Mitselos, Anna; Depoortere, Inge. (2009). Motilin and ghrelin as prokinetic drug targets.. Pharmacology & therapeutics, 123(2), 207-23. https://doi.org/10.1016/j.pharmthera.2009.04.004