Updated review of cyclotide chemistry (cyclic backbone, cystine knot, grafting technology) and biology (antimicrobial, anticancer, insecticidal, anti-HIV) with advancing drug scaffold applications.
Key findingUpdated cyclotide review covering chemical synthesis, structure determination, grafting methodology, and expanding biological activities (antimicrobia
What the researchers found
Updated cyclotide review covering chemical synthesis, structure determination, grafting methodology, and expanding biological activities (antimicrobial, anticancer, insecticidal, anti-HIV, uterotonic) — advancing from natural products to engineered drug scaffolds.
Why it matters
Relevant for cyclic-peptides, peptide-design, antimicrobial-peptides.
How the study worked
review study on cyclic-peptides, peptide-design.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
The chemistry and biology of cyclotides.
Current opinion in drug discovery & development, 10(2), 176-84
Citation
Craik, David J; Cemazar, Masa; Daly, Norelle L. (2007). The chemistry and biology of cyclotides.. Current opinion in drug discovery & development, 10(2), 176-84.