Cyclotide Chemistry and Biology: Nature's Ultra-Stable Circular Peptides Updated
Updated review of cyclotide chemistry (cyclic backbone, cystine knot, grafting technology) and biology (antimicrobial, anticancer, insecticidal, anti-HIV) with advancing drug scaffold applications.
Quick Facts
What This Study Found
Updated cyclotide review covering chemical synthesis, structure determination, grafting methodology, and expanding biological activities (antimicrobial, anticancer, insecticidal, anti-HIV, uterotonic) — advancing from natural products to engineered drug scaffolds.
Key Numbers
How They Did This
review study on cyclic-peptides, peptide-design.
Why This Research Matters
Relevant for cyclic-peptides, peptide-design, antimicrobial-peptides.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Updated cyclotide review covering chemical synthesis, structure determination, grafting methodology, and expanding biological activities (antimicrobia
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2007.
- Original Title:
- The chemistry and biology of cyclotides.
- Published In:
- Current opinion in drug discovery & development, 10(2), 176-84 (2007)
- Authors:
- Craik, David J(14), Cemazar, Masa(2), Daly, Norelle L(9)
- Database ID:
- RPEP-01217
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
Cyclotide Chemistry and Biology: Nature's Ultra-Stable Circular Peptides Updated
What was found?
Updated review of cyclotide chemistry (cyclic backbone, cystine knot, grafting technology) and biology (antimicrobial, anticancer, insecticidal, anti-HIV) with advancing drug scaffold applications.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01217APA
Craik, David J; Cemazar, Masa; Daly, Norelle L. (2007). The chemistry and biology of cyclotides.. Current opinion in drug discovery & development, 10(2), 176-84.
MLA
Craik, David J, et al. "The chemistry and biology of cyclotides.." Current opinion in drug discovery & development, 2007.
RethinkPeptides
RethinkPeptides Research Database. "The chemistry and biology of cyclotides." RPEP-01217. Retrieved from https://rethinkpeptides.com/research/craik-2007-the-chemistry-and-biology
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.