Updated review of cyclotides and related macrocyclic peptides as drug scaffolds, covering new grafting applications, oral stability data, and expanded bioactivity profiles for clinical drug development.
Key findingUpdated cyclotide drug scaffold review covering recent advances: new grafting applications for diverse therapeutic targets, confirmed oral stability a
What the researchers found
Updated cyclotide drug scaffold review covering recent advances: new grafting applications for diverse therapeutic targets, confirmed oral stability and bioavailability, expanded bioactivity profiles, and progress toward clinical macrocyclic peptide drugs.
Why it matters
Relevant for cyclic-peptides, peptide-design, bioavailability.
How the study worked
review study on cyclic-peptides, peptide-design.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
The cyclotides and related macrocyclic peptides as scaffolds in drug design.
Current opinion in drug discovery & development, 9(2), 251-60
Citation
Craik, David J; Cemazar, Masa; Daly, Norelle L. (2006). The cyclotides and related macrocyclic peptides as scaffolds in drug design.. Current opinion in drug discovery & development, 9(2), 251-60.