Cyclotides and Macrocyclic Peptides: Updated Drug Design Scaffolds in 2006
Updated review of cyclotides and related macrocyclic peptides as drug scaffolds, covering new grafting applications, oral stability data, and expanded bioactivity profiles for clinical drug development.
Quick Facts
What This Study Found
Updated cyclotide drug scaffold review covering recent advances: new grafting applications for diverse therapeutic targets, confirmed oral stability and bioavailability, expanded bioactivity profiles, and progress toward clinical macrocyclic peptide drugs.
Key Numbers
How They Did This
review study on cyclic-peptides, peptide-design.
Why This Research Matters
Relevant for cyclic-peptides, peptide-design, bioavailability.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Updated cyclotide drug scaffold review covering recent advances: new grafting applications for diverse therapeutic targets, confirmed oral stability a
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2006.
- Original Title:
- The cyclotides and related macrocyclic peptides as scaffolds in drug design.
- Published In:
- Current opinion in drug discovery & development, 9(2), 251-60 (2006)
- Authors:
- Craik, David J(14), Cemazar, Masa(2), Daly, Norelle L(9)
- Database ID:
- RPEP-01126
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
Cyclotides and Macrocyclic Peptides: Updated Drug Design Scaffolds in 2006
What was found?
Updated review of cyclotides and related macrocyclic peptides as drug scaffolds, covering new grafting applications, oral stability data, and expanded bioactivity profiles for clinical drug development.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01126APA
Craik, David J; Cemazar, Masa; Daly, Norelle L. (2006). The cyclotides and related macrocyclic peptides as scaffolds in drug design.. Current opinion in drug discovery & development, 9(2), 251-60.
MLA
Craik, David J, et al. "The cyclotides and related macrocyclic peptides as scaffolds in drug design.." Current opinion in drug discovery & development, 2006.
RethinkPeptides
RethinkPeptides Research Database. "The cyclotides and related macrocyclic peptides as scaffolds..." RPEP-01126. Retrieved from https://rethinkpeptides.com/research/craik-2006-the-cyclotides-and-related
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.