Kisspeptin modulates sexual and emotional brain processing in humans.
Quick Facts
What This Study Found
Kisspeptin enhanced limbic brain activity (amygdala, cingulate, globus pallidus, thalamus, putamen) specifically in response to sexual stimuli in 29 healthy men, while also reducing negative mood.
Key Numbers
29 healthy men; enhanced activity in amygdala, cingulate, globus pallidus, posterior thalamus, putamen; specific to sexual stimuli
How They Did This
Double-blind, placebo-controlled, 2-way crossover fMRI study in 29 healthy heterosexual men receiving kisspeptin-54 or saline infusion.
Why This Research Matters
First evidence in humans that kisspeptin modulates sexual brain processing through limbic pathways, linking reproductive hormones to emotional brain function.
What This Study Doesn't Tell Us
Male participants only. Single session. IV infusion not reflecting physiological kisspeptin release patterns.
Trust & Context
- Original Title:
- Kisspeptin modulates sexual and emotional brain processing in humans.
- Published In:
- The Journal of clinical investigation, 127(2), 709-719 (2017)
- Authors:
- Comninos, Alexander N(2), Wall, Matthew B, Demetriou, Lysia, Shah, Amar J, Clarke, Sophie A, Narayanaswamy, Shakunthala, Neher, Asija, Bloom, Stuart R, Filbey, Francis M, Dhillo, Waljit S
- Database ID:
- RPEP-03248
Evidence Hierarchy
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-03248APA
Comninos, Alexander N; Wall, Matthew B; Demetriou, Lysia; Shah, Amar J; Clarke, Sophie A; Narayanaswamy, Shakunthala; Neber, Asija; Bloom, Stuart R; Filbey, Francis M; Dhillo, Waljit S. (2017). Kisspeptin modulates sexual and emotional brain processing in humans.. The Journal of clinical investigation, 127(2), 709-719. https://doi.org/10.1172/JCI89519
MLA
Comninos, Alexander N, et al. "Kisspeptin modulates sexual and emotional brain processing in humans.." The Journal of clinical investigation, 2017. https://doi.org/10.1172/JCI89519
RethinkPeptides
RethinkPeptides Research Database. "Kisspeptin modulates sexual and emotional brain processing i..." RPEP-03248. Retrieved from https://rethinkpeptides.com/research/comninos-2017-kisspeptin-modulates-sexual-and
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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.