Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide.

RPEP-105122025Coassolo, Laetitia; B Danneskiold-Samsøe, Niels; Nguyen, Quennie; Wiggenhorn, Amanda; Zhao, Meng; Wang, David Cheng-Hao; Toomer, David; Lone, Jameel; Wei, Yichao; Patel, Aayan; Liparulo, Irene; Kavi, Deniz; Wat, Lianna W; Reghupaty, Saranya Chidambaranathan; Kim, Julie Jae; Asemi, Tina; Bielczyk-Maczynska, Ewa; Li, Veronica L; Moya-Garzon, Maria Dolores; Krentz, Nicole A J; Stahl, Andreas; Chou, Danny Hung-Chieh; Luo, Liqun; Svensson, Katrin J

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Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide.

Nature, 641(8061), 192-201

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Coassolo, Laetitia; B Danneskiold-Samsøe, Niels; Nguyen, Quennie; Wiggenhorn, Amanda; Zhao, Meng; Wang, David Cheng-Hao; Toomer, David; Lone, Jameel; Wei, Yichao; Patel, Aayan; Liparulo, Irene; Kavi, Deniz; Wat, Lianna W; Reghupaty, Saranya Chidambaranathan; Kim, Julie Jae; Asemi, Tina; Bielczyk-Maczynska, Ewa; Li, Veronica L; Moya-Garzon, Maria Dolores; Krentz, Nicole A J; Stahl, Andreas; Chou, Danny Hung-Chieh; Luo, Liqun; Svensson, Katrin J. (2025). Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide.. Nature, 641(8061), 192-201. https://doi.org/10.1038/s41586-025-08683-y