This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Captopril increased PKCβI expression in astrocytes, with significant increases in substance P and bradykinin levels.
Why it matters
Understanding how ACE inhibitors affect brain cell signaling can help in developing treatments for neurological conditions. This research may provide insights into the mechanisms of pain and inflammation in the brain.
How the study worked
The study used immunocytochemistry and Western blot analysis on primary cultured astrocytes to assess protein levels and expression.
What this study cannot tell us
The study was conducted in cultured astrocytes, which may not fully replicate in vivo conditions in living organisms.
Read the original research
Inhibition of angiotensin converting enzyme increases PKCβI isoform expression via activation of substance P and bradykinin receptors in cultured astrocytes of mice.
Journal of veterinary science, 24(2), e26
Citation
Choi, Jae-Gyun; Choi, Sheu-Ran; Kang, Dong-Wook; Shin, Hyun Jin; Lee, Miae; Hwang, Jungmo; Kim, Hyun-Woo. (2023). Inhibition of angiotensin converting enzyme increases PKCβI isoform expression via activation of substance P and bradykinin receptors in cultured astrocytes of mice.. Journal of veterinary science, 24(2), e26. https://doi.org/10.4142/jvs.22275