Inhibition of angiotensin converting enzyme increases PKCβI isoform expression via activation of substance P and bradykinin receptors in cultured astrocytes of mice.
Quick Facts
What This Study Found
Captopril increased PKCβI expression in astrocytes, with significant increases in substance P and bradykinin levels.
Key Numbers
How They Did This
The study used immunocytochemistry and Western blot analysis on primary cultured astrocytes to assess protein levels and expression.
Why This Research Matters
Understanding how ACE inhibitors affect brain cell signaling can help in developing treatments for neurological conditions. This research may provide insights into the mechanisms of pain and inflammation in the brain.
What This Study Doesn't Tell Us
The study was conducted in cultured astrocytes, which may not fully replicate in vivo conditions in living organisms.
Trust & Context
- Original Title:
- Inhibition of angiotensin converting enzyme increases PKCβI isoform expression via activation of substance P and bradykinin receptors in cultured astrocytes of mice.
- Published In:
- Journal of veterinary science, 24(2), e26 (2023)
- Authors:
- Choi, Jae-Gyun, Choi, Sheu-Ran, Kang, Dong-Wook, Shin, Hyun Jin, Lee, Miae, Hwang, Jungmo, Kim, Hyun-Woo
- Database ID:
- RPEP-06799
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06799APA
Choi, Jae-Gyun; Choi, Sheu-Ran; Kang, Dong-Wook; Shin, Hyun Jin; Lee, Miae; Hwang, Jungmo; Kim, Hyun-Woo. (2023). Inhibition of angiotensin converting enzyme increases PKCβI isoform expression via activation of substance P and bradykinin receptors in cultured astrocytes of mice.. Journal of veterinary science, 24(2), e26. https://doi.org/10.4142/jvs.22275
MLA
Choi, Jae-Gyun, et al. "Inhibition of angiotensin converting enzyme increases PKCβI isoform expression via activation of substance P and bradykinin receptors in cultured astrocytes of mice.." Journal of veterinary science, 2023. https://doi.org/10.4142/jvs.22275
RethinkPeptides
RethinkPeptides Research Database. "Inhibition of angiotensin converting enzyme increases PKCβI ..." RPEP-06799. Retrieved from https://rethinkpeptides.com/research/choi-2023-inhibition-of-angiotensin-converting
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.