Mitochondria-Targeted Peptides Dramatically Reduce Heart Attack Size in Rats
Mitochondria-targeted peptides (SS-31/Bendavia) reduced myocardial infarct size by up to 60% in rats when given before or during reperfusion — demonstrating potent cardioprotection through mitochondrial protection.
Quick Facts
What This Study Found
Mitochondria-targeted peptides (SS-31 and analogs) reduced myocardial infarct size by up to 60% in rat ischemia-reperfusion, with efficacy when given before ischemia or at reperfusion — demonstrating potent cardioprotection through preservation of mitochondrial function.
Key Numbers
How They Did This
animal-study study on opioid-peptides, cardiovascular.
Why This Research Matters
Relevant for opioid-peptides, cardiovascular, neuroprotection.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Mitochondria-targeted peptides (SS-31 and analogs) reduced myocardial infarct size by up to 60% in rat ischemia-reperfusion, with efficacy when given
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Potent mitochondria-targeted peptides reduce myocardial infarction in rats.
- Published In:
- Coronary artery disease, 18(3), 215-20 (2007)
- Authors:
- Cho, Janghyun, Won, Kyungheon, Wu, DunLi(2), Soong, Yi, Liu, Shaoyi, Szeto, Hazel H, Hong, Mun K
- Database ID:
- RPEP-01216
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Mitochondria-Targeted Peptides Dramatically Reduce Heart Attack Size in Rats
What was found?
Mitochondria-targeted peptides (SS-31/Bendavia) reduced myocardial infarct size by up to 60% in rats when given before or during reperfusion — demonstrating potent cardioprotection through mitochondrial protection.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01216APA
Cho, Janghyun; Won, Kyungheon; Wu, DunLi; Soong, Yi; Liu, Shaoyi; Szeto, Hazel H; Hong, Mun K. (2007). Potent mitochondria-targeted peptides reduce myocardial infarction in rats.. Coronary artery disease, 18(3), 215-20.
MLA
Cho, Janghyun, et al. "Potent mitochondria-targeted peptides reduce myocardial infarction in rats.." Coronary artery disease, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Potent mitochondria-targeted peptides reduce myocardial infa..." RPEP-01216. Retrieved from https://rethinkpeptides.com/research/cho-2007-potent-mitochondriatargeted-peptides-reduce
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.