Protective effect of gelatin peptides from pacific cod skin against photoaging by inhibiting the expression of MMPs via MAPK signaling pathway.
Quick Facts
What This Study Found
Gelatin hydrolysate (CH) from Pacific cod skin significantly inhibited the UV-induced upregulation and activity of MMP-1, MMP-3, and MMP-9 in mouse skin, preserved collagen content, and suppressed MAPK pathway activation including ERK and p38 phosphorylation, thereby protecting against photoaging.
Key Numbers
How They Did This
The study used a mouse skin photoaging model exposed to UV irradiation. Quantitative real-time PCR and ELISA assays measured MMP expression and activity, while molecular analyses assessed MAPK signaling pathway components after treatment with gelatin hydrolysate (CH) derived from Pacific cod skin.
Why This Research Matters
Understanding how natural peptides inhibit enzymes that degrade collagen can lead to new treatments or skincare products that prevent or reduce skin aging caused by UV exposure. This could improve skin health and appearance.
What This Study Doesn't Tell Us
The study was conducted in a mouse model, so results may not fully translate to humans. The exact dosage and delivery method for optimal effects in humans remain to be established.
Trust & Context
- Original Title:
- Protective effect of gelatin peptides from pacific cod skin against photoaging by inhibiting the expression of MMPs via MAPK signaling pathway.
- Published In:
- Journal of photochemistry and photobiology. B, Biology, 165, 34-41 (2016)
- Authors:
- Chen, Tiejun, Hou, Hu, Fan, Yan, Wang, Shikai, Chen, Qianru, Si, Leilei, Li, Bafang
- Database ID:
- RPEP-02893
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-02893APA
Chen, Tiejun; Hou, Hu; Fan, Yan; Wang, Shikai; Chen, Qianru; Si, Leilei; Li, Bafang. (2016). Protective effect of gelatin peptides from pacific cod skin against photoaging by inhibiting the expression of MMPs via MAPK signaling pathway.. Journal of photochemistry and photobiology. B, Biology, 165, 34-41. https://doi.org/10.1016/j.jphotobiol.2016.10.015
MLA
Chen, Tiejun, et al. "Protective effect of gelatin peptides from pacific cod skin against photoaging by inhibiting the expression of MMPs via MAPK signaling pathway.." Journal of photochemistry and photobiology. B, 2016. https://doi.org/10.1016/j.jphotobiol.2016.10.015
RethinkPeptides
RethinkPeptides Research Database. "Protective effect of gelatin peptides from pacific cod skin ..." RPEP-02893. Retrieved from https://rethinkpeptides.com/research/chen-2016-protective-effect-of-gelatin
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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.