Nociceptin/orphanin FQ blocked antinociception induced by mu, kappa, AND delta opioid agonists at the spinal level, confirming it as a universal anti-opioid peptide that counteracts all forms of opioid-mediated pain relief.
Key findingNociceptin/OFQ blocked spinal antinociception from mu (DAMGO), kappa (U50,488H), and delta (DPDPE) opioid agonists in the cold water tail-flick test,
What the researchers found
Nociceptin/OFQ blocked spinal antinociception from mu (DAMGO), kappa (U50,488H), and delta (DPDPE) opioid agonists in the cold water tail-flick test, confirming nociceptin as a universal anti-opioid peptide opposing all three opioid receptor systems.
Why it matters
Relevant for opioid-peptides, neuropeptides, pain.
How the study worked
animal-study study on opioid-peptides, neuropeptides.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test.
European journal of pharmacology, 557(1), 32-6
Citation
Chen, Xiaohong; Geller, Ellen B; Adler, Martin W. (2007). Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test.. European journal of pharmacology, 557(1), 32-6.