Nociceptin Blocks ALL Three Types of Opioid Pain Relief in the Spinal Cord
Nociceptin/orphanin FQ blocked antinociception induced by mu, kappa, AND delta opioid agonists at the spinal level, confirming it as a universal anti-opioid peptide that counteracts all forms of opioid-mediated pain relief.
Quick Facts
What This Study Found
Nociceptin/OFQ blocked spinal antinociception from mu (DAMGO), kappa (U50,488H), and delta (DPDPE) opioid agonists in the cold water tail-flick test, confirming nociceptin as a universal anti-opioid peptide opposing all three opioid receptor systems.
Key Numbers
How They Did This
animal-study study on opioid-peptides, neuropeptides.
Why This Research Matters
Relevant for opioid-peptides, neuropeptides, pain.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Nociceptin/OFQ blocked spinal antinociception from mu (DAMGO), kappa (U50,488H), and delta (DPDPE) opioid agonists in the cold water tail-flick test,
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test.
- Published In:
- European journal of pharmacology, 557(1), 32-6 (2007)
- Authors:
- Chen, Xiaohong, Geller, Ellen B, Adler, Martin W
- Database ID:
- RPEP-01214
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Nociceptin Blocks ALL Three Types of Opioid Pain Relief in the Spinal Cord
What was found?
Nociceptin/orphanin FQ blocked antinociception induced by mu, kappa, AND delta opioid agonists at the spinal level, confirming it as a universal anti-opioid peptide that counteracts all forms of opioid-mediated pain relief.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01214APA
Chen, Xiaohong; Geller, Ellen B; Adler, Martin W. (2007). Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test.. European journal of pharmacology, 557(1), 32-6.
MLA
Chen, Xiaohong, et al. "Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test.." European journal of pharmacology, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Nociceptin/orphanin FQ blocks the antinociception induced by..." RPEP-01214. Retrieved from https://rethinkpeptides.com/research/chen-2007-nociceptinorphanin-fq-blocks-the
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.