Self-assembling peptide scaffolds incorporating MMP-sensitive substrates degraded in response to wound healing enzymes, creating smart biomaterials that respond to the tissue repair environment.
Key findingSelf-assembling peptide hydrogels incorporating matrix metalloproteinase (MMP)-sensitive substrate sequences degraded in response to cell-secreted MMP
What the researchers found
Self-assembling peptide hydrogels incorporating matrix metalloproteinase (MMP)-sensitive substrate sequences degraded in response to cell-secreted MMPs during tissue repair, creating enzyme-responsive smart scaffolds that adapt to the wound healing environment.
Why it matters
Relevant for peptide-design, peptide-delivery.
How the study worked
in-vitro study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides - a model for biofunctional scaffolds.
Biomaterials, 29(11), 1713-9
Citation
Chau, Ying; Luo, Ying; Cheung, Alex C Y; Nagai, Yusuke; Zhang, Shuguang; Kobler, James B; Zeitels, Steven M; Langer, Robert. (2008). Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides - a model for biofunctional scaffolds.. Biomaterials, 29(11), 1713-9. https://doi.org/10.1016/j.biomaterials.2007.11.046