Smart Peptide Scaffolds: Self-Assembling Gels That Respond to Wound Healing Enzymes
Self-assembling peptide scaffolds incorporating MMP-sensitive substrates degraded in response to wound healing enzymes, creating smart biomaterials that respond to the tissue repair environment.
Quick Facts
What This Study Found
Self-assembling peptide hydrogels incorporating matrix metalloproteinase (MMP)-sensitive substrate sequences degraded in response to cell-secreted MMPs during tissue repair, creating enzyme-responsive smart scaffolds that adapt to the wound healing environment.
Key Numbers
How They Did This
in-vitro study.
Why This Research Matters
Relevant for peptide-design, peptide-delivery.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Self-assembling peptide hydrogels incorporating matrix metalloproteinase (MMP)-sensitive substrate sequences degraded in response to cell-secreted MMP
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides - a model for biofunctional scaffolds.
- Published In:
- Biomaterials, 29(11), 1713-9 (2008)
- Authors:
- Chau, Ying, Luo, Ying(4), Cheung, Alex C Y, Nagai, Yusuke, Zhang, Shuguang, Kobler, James B, Zeitels, Steven M, Langer, Robert
- Database ID:
- RPEP-01321
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Smart Peptide Scaffolds: Self-Assembling Gels That Respond to Wound Healing Enzymes
What was found?
Self-assembling peptide scaffolds incorporating MMP-sensitive substrates degraded in response to wound healing enzymes, creating smart biomaterials that respond to the tissue repair environment.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01321APA
Chau, Ying; Luo, Ying; Cheung, Alex C Y; Nagai, Yusuke; Zhang, Shuguang; Kobler, James B; Zeitels, Steven M; Langer, Robert. (2008). Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides - a model for biofunctional scaffolds.. Biomaterials, 29(11), 1713-9. https://doi.org/10.1016/j.biomaterials.2007.11.046
MLA
Chau, Ying, et al. "Incorporation of a matrix metalloproteinase-sensitive substrate into self-assembling peptides - a model for biofunctional scaffolds.." Biomaterials, 2008. https://doi.org/10.1016/j.biomaterials.2007.11.046
RethinkPeptides
RethinkPeptides Research Database. "Incorporation of a matrix metalloproteinase-sensitive substr..." RPEP-01321. Retrieved from https://rethinkpeptides.com/research/chau-2008-incorporation-of-a-matrix
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.