Systematic optimization of the native glucagon sequence produced analogs with improved stability, selectivity, and pharmacokinetics for potential dual GLP-1/glucagon receptor agonist obesity and diabetes drugs.
Key findingSystematic optimization of the native glucagon sequence produced analogs with improved stability, selectivity, and pharmacokinetics for potential dual
What the researchers found
Systematic optimization of the native glucagon sequence produced analogs with improved stability, selectivity, and pharmacokinetics for potential dual GLP-1/glucagon receptor agonist obesity and diabetes drugs.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2010.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
Common questions
What was studied?
What was found?
Read the original research
Optimization of the native glucagon sequence for medicinal purposes.
Journal of diabetes science and technology, 4(6), 1322-31
Citation
Chabenne, Joseph R; DiMarchi, Maria A; Gelfanov, Vasily M; DiMarchi, Richard D. (2010). Optimization of the native glucagon sequence for medicinal purposes.. Journal of diabetes science and technology, 4(6), 1322-31.