A careful reanalysis showed adenosine does NOT bind the GHS-R1a receptor, contradicting earlier reports — the previously reported adenosine-GHS-R interaction was an experimental artifact.
Key findingRigorous binding and functional assays demonstrated adenosine does NOT activate GHS-R1a, contradicting two previous studies — the earlier reported ade
What the researchers found
Rigorous binding and functional assays demonstrated adenosine does NOT activate GHS-R1a, contradicting two previous studies — the earlier reported adenosine-ghrelin receptor interaction was an experimental artifact, not a genuine physiological interaction.
Why it matters
Relevant for ghrp, receptor-signaling.
How the study worked
in-vitro study on ghrp, receptor-signaling.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Adenosine does not bind to the growth hormone secretagogue receptor type-1a (GHS-R1a).
The Journal of endocrinology, 191(1), 147-57
Citation
Carreira, Marcos C; Camiña, Jesus P; Díaz-Rodríguez, Esther; Alvear-Perez, Rodrigo; Llorens-Cortes, Catherine; Casanueva, Felipe F. (2006). Adenosine does not bind to the growth hormone secretagogue receptor type-1a (GHS-R1a).. The Journal of endocrinology, 191(1), 147-57.