This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
CPP12-2 shows up to 3.8-fold higher cytosolic entry efficiency than CPP12.
Why it matters
This research could lead to more effective drug delivery systems, particularly for therapies requiring low doses. Improved cellular uptake can enhance the efficacy of treatments.
How the study worked
The study involved synthesizing CPP12 analogs and testing their ability to enter cells under various conditions.
What this study cannot tell us
The study primarily focused on in vitro and in vivo models, which may not fully represent human responses.
Read the original research
Discovery of a Cyclic Cell-Penetrating Peptide with Improved Endosomal Escape and Cytosolic Delivery Efficiency.
Molecular pharmaceutics, 19(5), 1378-1388
Citation
Buyanova, Marina; Sahni, Ashweta; Yang, Rui; Sarkar, Amar; Salim, Heba; Pei, Dehua. (2022). Discovery of a Cyclic Cell-Penetrating Peptide with Improved Endosomal Escape and Cytosolic Delivery Efficiency.. Molecular pharmaceutics, 19(5), 1378-1388. https://doi.org/10.1021/acs.molpharmaceut.1c00924