Discovery of a Cyclic Cell-Penetrating Peptide with Improved Endosomal Escape and Cytosolic Delivery Efficiency.
Quick Facts
What This Study Found
CPP12-2 shows up to 3.8-fold higher cytosolic entry efficiency than CPP12.
Key Numbers
How They Did This
The study involved synthesizing CPP12 analogs and testing their ability to enter cells under various conditions.
Why This Research Matters
This research could lead to more effective drug delivery systems, particularly for therapies requiring low doses. Improved cellular uptake can enhance the efficacy of treatments.
What This Study Doesn't Tell Us
The study primarily focused on in vitro and in vivo models, which may not fully represent human responses.
Trust & Context
- Original Title:
- Discovery of a Cyclic Cell-Penetrating Peptide with Improved Endosomal Escape and Cytosolic Delivery Efficiency.
- Published In:
- Molecular pharmaceutics, 19(5), 1378-1388 (2022)
- Authors:
- Buyanova, Marina, Sahni, Ashweta, Yang, Rui(3), Sarkar, Amar, Salim, Heba, Pei, Dehua
- Database ID:
- RPEP-06024
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06024APA
Buyanova, Marina; Sahni, Ashweta; Yang, Rui; Sarkar, Amar; Salim, Heba; Pei, Dehua. (2022). Discovery of a Cyclic Cell-Penetrating Peptide with Improved Endosomal Escape and Cytosolic Delivery Efficiency.. Molecular pharmaceutics, 19(5), 1378-1388. https://doi.org/10.1021/acs.molpharmaceut.1c00924
MLA
Buyanova, Marina, et al. "Discovery of a Cyclic Cell-Penetrating Peptide with Improved Endosomal Escape and Cytosolic Delivery Efficiency.." Molecular pharmaceutics, 2022. https://doi.org/10.1021/acs.molpharmaceut.1c00924
RethinkPeptides
RethinkPeptides Research Database. "Discovery of a Cyclic Cell-Penetrating Peptide with Improved..." RPEP-06024. Retrieved from https://rethinkpeptides.com/research/buyanova-2022-discovery-of-a-cyclic
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.