Ghrelin Protects the Stomach From Ischemia-Reperfusion Injury Through Prostaglandins
Ghrelin protected against gastric ischemia-reperfusion injury through a prostaglandin/cyclooxygenase-dependent pathway, adding gastroprotection to ghrelin's growing list of GI effects.
Quick Facts
What This Study Found
Ghrelin's gastroprotective effect against ischemia-reperfusion injury was mediated through the prostaglandin/COX pathway, with COX inhibitors (indomethacin) blocking the protection — identifying the molecular mechanism for ghrelin's gastric mucosal defense.
Key Numbers
How They Did This
animal-study study on ghrp, gut-healing.
Why This Research Matters
Relevant for ghrp, gut-healing.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Ghrelin's gastroprotective effect against ischemia-reperfusion injury was mediated through the prostaglandin/COX pathway, with COX inhibitors (indomet
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Prostaglandin/cyclooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury.
- Published In:
- The Journal of pharmacology and experimental therapeutics, 319(1), 477-87 (2006)
- Authors:
- Brzozowski, Tomasz, Konturek, Peter C, Sliwowski, Zbigniew, Pajdo, Robert, Drozdowicz, Danuta, Kwiecien, Slawomir, Burnat, Grzegorz, Konturek, Stanislaw J, Pawlik, Wieslaw W
- Database ID:
- RPEP-01120
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Ghrelin Protects the Stomach From Ischemia-Reperfusion Injury Through Prostaglandins
What was found?
Ghrelin protected against gastric ischemia-reperfusion injury through a prostaglandin/cyclooxygenase-dependent pathway, adding gastroprotection to ghrelin's growing list of GI effects.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01120APA
Brzozowski, Tomasz; Konturek, Peter C; Sliwowski, Zbigniew; Pajdo, Robert; Drozdowicz, Danuta; Kwiecien, Slawomir; Burnat, Grzegorz; Konturek, Stanislaw J; Pawlik, Wieslaw W. (2006). Prostaglandin/cyclooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury.. The Journal of pharmacology and experimental therapeutics, 319(1), 477-87.
MLA
Brzozowski, Tomasz, et al. "Prostaglandin/cyclooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury.." The Journal of pharmacology and experimental therapeutics, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Prostaglandin/cyclooxygenase pathway in ghrelin-induced gast..." RPEP-01120. Retrieved from https://rethinkpeptides.com/research/brzozowski-2006-prostaglandincyclooxygenase-pathway-in-ghrelininduced
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.