Ghrelin protected against gastric ischemia-reperfusion injury through a prostaglandin/cyclooxygenase-dependent pathway, adding gastroprotection to ghrelin's growing list of GI effects.
Key findingGhrelin's gastroprotective effect against ischemia-reperfusion injury was mediated through the prostaglandin/COX pathway, with COX inhibitors (indomet
What the researchers found
Ghrelin's gastroprotective effect against ischemia-reperfusion injury was mediated through the prostaglandin/COX pathway, with COX inhibitors (indomethacin) blocking the protection — identifying the molecular mechanism for ghrelin's gastric mucosal defense.
Why it matters
Relevant for ghrp, gut-healing.
How the study worked
animal-study study on ghrp, gut-healing.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Prostaglandin/cyclooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury.
The Journal of pharmacology and experimental therapeutics, 319(1), 477-87
Citation
Brzozowski, Tomasz; Konturek, Peter C; Sliwowski, Zbigniew; Pajdo, Robert; Drozdowicz, Danuta; Kwiecien, Slawomir; Burnat, Grzegorz; Konturek, Stanislaw J; Pawlik, Wieslaw W. (2006). Prostaglandin/cyclooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury.. The Journal of pharmacology and experimental therapeutics, 319(1), 477-87.