Comprehensive review of GHS-R1a receptor pharmacology tools — agonists, antagonists, inverse agonists — revealing the receptor's role in both GH secretion and feeding, with implications for separating these functions therapeutically.
Key findingGHS-R1a pharmacological tools (agonists, antagonists, inverse agonists) revealed the receptor controls both GH secretion and feeding behavior, with re
What the researchers found
GHS-R1a pharmacological tools (agonists, antagonists, inverse agonists) revealed the receptor controls both GH secretion and feeding behavior, with receptor modification studies suggesting these functions may be partially separable for therapeutic benefit.
Why it matters
Relevant for ghrp, weight-loss, receptor-signaling.
How the study worked
review study.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Ghrelin control of GH secretion and feeding behaviour: the role of the GHS-R1a receptor studied in vivo and in vitro using novel non-peptide ligands.
Eating and weight disorders : EWD, 13(3), e67-74
Citation
Bresciani, E; Tamiazzo, L; Torsello, A; Bulgarelli, I; Rapetti, D; Caporali, S; Perrissoud, D; Moulin, A; Fehrentz, J A; Martinez, J; Locatelli, V. (2008). Ghrelin control of GH secretion and feeding behaviour: the role of the GHS-R1a receptor studied in vivo and in vitro using novel non-peptide ligands.. Eating and weight disorders : EWD, 13(3), e67-74.