Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.
Quick Facts
What This Study Found
SAR441255 improved glycemic control and weight loss compared to dual receptor agonists.
Key Numbers
How They Did This
The study involved preclinical testing in rodent models and a mixed-meal tolerance test in healthy human subjects.
Why This Research Matters
This research highlights a potential new treatment for obesity and diabetes by leveraging multiple hormonal pathways. It may lead to more effective therapies with fewer side effects.
What This Study Doesn't Tell Us
The study primarily involved animal models and a small group of healthy subjects, which may limit the generalizability of the findings.
Trust & Context
- Original Title:
- Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.
- Published In:
- Cell metabolism, 34(1), 59-74.e10 (2022)
- Authors:
- Bossart, Martin, Wagner, Michael(3), Elvert, Ralf, Evers, Andreas, Hübschle, Thomas, Kloeckener, Tim, Lorenz, Katrin, Moessinger, Christine, Eriksson, Olof, Velikyan, Irina, Pierrou, Stefan, Johansson, Lars, Dietert, Gabriele, Dietz-Baum, Yasmin, Kissner, Thomas, Nowotny, Irene, Einig, Christine, Jan, Christelle, Rharbaoui, Faiza, Gassenhuber, Johann, Prochnow, Hans-Peter, Agueusop, Inoncent, Porksen, Niels, Smith, William B, Nitsche, Almut, Konkar, Anish
- Database ID:
- RPEP-06013
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06013APA
Bossart, Martin; Wagner, Michael; Elvert, Ralf; Evers, Andreas; Hübschle, Thomas; Kloeckener, Tim; Lorenz, Katrin; Moessinger, Christine; Eriksson, Olof; Velikyan, Irina; Pierrou, Stefan; Johansson, Lars; Dietert, Gabriele; Dietz-Baum, Yasmin; Kissner, Thomas; Nowotny, Irene; Einig, Christine; Jan, Christelle; Rharbaoui, Faiza; Gassenhuber, Johann; Prochnow, Hans-Peter; Agueusop, Inoncent; Porksen, Niels; Smith, William B; Nitsche, Almut; Konkar, Anish. (2022). Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.. Cell metabolism, 34(1), 59-74.e10. https://doi.org/10.1016/j.cmet.2021.12.005
MLA
Bossart, Martin, et al. "Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.." Cell metabolism, 2022. https://doi.org/10.1016/j.cmet.2021.12.005
RethinkPeptides
RethinkPeptides Research Database. "Effects on weight loss and glycemic control with SAR441255, ..." RPEP-06013. Retrieved from https://rethinkpeptides.com/research/bossart-2022-effects-on-weight-loss
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.