Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial.

Borlaug, Barry A et al.·Nature medicine·2025·
RPEP-102022025RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Not classified
Evidence
Not graded
Sample
Not reported

What This Study Found

Key Numbers

How They Did This

Why This Research Matters

What This Study Doesn't Tell Us

Trust & Context

Original Title:
Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial.
Published In:
Nature medicine, 31(2), 544-551 (2025)
Database ID:
RPEP-10202

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study
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Cite This Study

RPEP-10202·https://rethinkpeptides.com/research/RPEP-10202

APA

Borlaug, Barry A; Zile, Michael R; Kramer, Christopher M; Baum, Seth J; Hurt, Karla; Litwin, Sheldon E; Murakami, Masahiro; Ou, Yang; Upadhyay, Navneet; Packer, Milton. (2025). Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial.. Nature medicine, 31(2), 544-551. https://doi.org/10.1038/s41591-024-03374-z

MLA

Borlaug, Barry A, et al. "Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial.." Nature medicine, 2025. https://doi.org/10.1038/s41591-024-03374-z

RethinkPeptides

RethinkPeptides Research Database. "Effects of tirzepatide on circulatory overload and end-organ..." RPEP-10202. Retrieved from https://rethinkpeptides.com/research/borlaug-2025-effects-of-tirzepatide-on

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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.