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Peripheral Inflammation Changes How Pain Neurons Respond to Substance P

evidence
The takeaway

Peripheral inflammation altered the desensitization of substance P-evoked currents in dorsal root ganglion neurons, explaining why inflamed tissue has enhanced pain sensitivity through neuropeptide receptor changes.

Key finding

Peripheral inflammation altered the desensitization of substance P-evoked currents in dorsal root ganglion neurons, explaining why inflamed tissue has

What the researchers found

Peripheral inflammation altered the desensitization of substance P-evoked currents in dorsal root ganglion neurons, explaining why inflamed tissue has enhanced pain sensitivity through neuropeptide receptor changes.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2011.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
Peripheral Inflammation Changes How Pain Neurons Respond to Substance P
What was found?
Peripheral inflammation altered the desensitization of substance P-evoked currents in dorsal root ganglion neurons, explaining why inflamed tissue has enhanced pain sensitivity through neuropeptide receptor changes.

Read the original research

Peripheral inflammation alters desensitization of substance P-evoked current in rat dorsal root ganglion neurons.

European journal of pharmacology, 670(2-3), 495-9

Citation

Bie, Bihua; Zhao, Zhi-Qi. (2011). Peripheral inflammation alters desensitization of substance P-evoked current in rat dorsal root ganglion neurons.. European journal of pharmacology, 670(2-3), 495-9. https://doi.org/10.1016/j.ejphar.2011.09.004