Mice with eradicated H. pylori maintained abnormal feeding behavior through persistent changes in the gut-brain axis, suggesting the infection permanently reprograms appetite regulation even after successful treatment.
Key findingH. pylori eradication in mice left persistent abnormal feeding behavior and gut-brain axis changes despite successful bacterial elimination, suggestin
What the researchers found
H. pylori eradication in mice left persistent abnormal feeding behavior and gut-brain axis changes despite successful bacterial elimination, suggesting the infection permanently reprograms appetite regulation — not all gut-brain changes reverse when the infection is cleared.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2009.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Role of gut-brain axis in persistent abnormal feeding behavior in mice following eradication of Helicobacter pylori infection.
American journal of physiology. Regulatory, integrative and comparative physiology, 296(3), R587-94
Citation
Bercik, Premysl; Verdú, Elena F; Foster, Jane A; Lu, Jun; Scharringa, Angela; Kean, Iain; Wang, Lu; Blennerhassett, Patricia; Collins, Stephen M. (2009). Role of gut-brain axis in persistent abnormal feeding behavior in mice following eradication of Helicobacter pylori infection.. American journal of physiology. Regulatory, integrative and comparative physiology, 296(3), R587-94. https://doi.org/10.1152/ajpregu.90752.2008