Spinal mu- and delta-opioid receptor activation potently inhibited substance P release from peripheral nociceptive nerves, revealing a specific presynaptic mechanism for spinal opioid-mediated pain suppression.
Key findingSpinal mu- and delta-opioid receptor activation potently inhibited substance P release from peripheral nociceptive nerves, revealing a specific presyn
What the researchers found
Spinal mu- and delta-opioid receptor activation potently inhibited substance P release from peripheral nociceptive nerves, revealing a specific presynaptic mechanism for spinal opioid-mediated pain suppression.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2011.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
Common questions
What was studied?
What was found?
Read the original research
Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(37), 13068-77
Citation
Beaudry, Hélène; Dubois, Dave; Gendron, Louis. (2011). Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.. The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(37), 13068-77. https://doi.org/10.1523/JNEUROSCI.1817-11.2011