Thymosin Alpha-1 Shows Antidepressant Effects: Small Study Results
Small study found indications of antidepressive effects of thymosin alpha-1, a thymic peptide, suggesting immune-modulating peptides may influence mood disorders.
Quick Facts
What This Study Found
Small study found indications of antidepressive effects of thymosin alpha-1, a thymic peptide, suggesting immune-modulating peptides may influence mood disorders.
Key Numbers
How They Did This
In publication.
Why This Research Matters
Relevant to peptide therapeutics.
The Bigger Picture
Advances peptide evidence.
What This Study Doesn't Tell Us
In publication.
Questions This Raises
- ?Long-term implications?
- ?Evidence comparison?
- ?Next steps?
Trust & Context
- Key Stat:
- Key finding Small study found indications of antidepressive effects of thymosin alpha-1, a thymic peptide, sugge
- Evidence Grade:
- Based on design.
- Study Age:
- Published in 2025.
- Original Title:
- Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression.
- Published In:
- Brain, behavior, & immunity - health, 43, 100934 (2025)
- Authors:
- Aynekulu Mersha, Daniël G, Fromme, Sarah E, van Boven, Frank, Arteaga-Henríquez, Gara, Wijkhuijs, Annemarie, van der Ent, Marianne, Bergmans, Raf, Baune, Bernard T, Drexhage, Hemmo A, Dalm, Virgil
- Database ID:
- RPEP-10027
Evidence Hierarchy
Frequently Asked Questions
What does this mean?
Small study found indications of antidepressive effects of thymosin alpha-1, a thymic peptide, suggesting immune-modulating peptides may influence mood disorders.
How reliable?
Consult publication.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-10027APA
Aynekulu Mersha, Daniël G; Fromme, Sarah E; van Boven, Frank; Arteaga-Henríquez, Gara; Wijkhuijs, Annemarie; van der Ent, Marianne; Bergmans, Raf; Baune, Bernard T; Drexhage, Hemmo A; Dalm, Virgil. (2025). Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression.. Brain, behavior, & immunity - health, 43, 100934. https://doi.org/10.1016/j.bbih.2024.100934
MLA
Aynekulu Mersha, Daniël G, et al. "Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression.." Brain, 2025. https://doi.org/10.1016/j.bbih.2024.100934
RethinkPeptides
RethinkPeptides Research Database. "Indications for an antidepressive effect of thymosin alpha-1..." RPEP-10027. Retrieved from https://rethinkpeptides.com/research/aynekulu-2025-indications-for-an-antidepressive
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.