Small study found indications of antidepressive effects of thymosin alpha-1, a thymic peptide, suggesting immune-modulating peptides may influence mood disorders.
Key findingSmall study found indications of antidepressive effects of thymosin alpha-1, a thymic peptide, sugge
What the researchers found
Small study found indications of antidepressive effects of thymosin alpha-1, a thymic peptide, suggesting immune-modulating peptides may influence mood disorders.
Why it matters
Relevant to peptide therapeutics.
How the study worked
In publication.
What this study cannot tell us
In publication.
How to read the evidence
Based on design.
When this study was published
Published in 2025.
The bigger picture
Advances peptide evidence.
Questions still open
- Long-term implications?
- Evidence comparison?
- Next steps?
Common questions
What does this mean?
How reliable?
Read the original research
Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression.
Brain, behavior, & immunity - health, 43, 100934
Citation
Aynekulu Mersha, Daniël G; Fromme, Sarah E; van Boven, Frank; Arteaga-Henríquez, Gara; Wijkhuijs, Annemarie; van der Ent, Marianne; Bergmans, Raf; Baune, Bernard T; Drexhage, Hemmo A; Dalm, Virgil. (2025). Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression.. Brain, behavior, & immunity - health, 43, 100934. https://doi.org/10.1016/j.bbih.2024.100934