A growth hormone-releasing peptide that binds both GHS-R (ghrelin receptor) and CD36 (scavenger receptor) upregulated cholesterol transport pathways, revealing how GH peptides may influence cardiovascular lipid metabolism.
Key findingA GH-releasing peptide binding both GHS-R and CD36 scavenger receptor upregulated sterol transporters (ABCA1, ABCG1) in macrophages, demonstrating GH
What the researchers found
A GH-releasing peptide binding both GHS-R and CD36 scavenger receptor upregulated sterol transporters (ABCA1, ABCG1) in macrophages, demonstrating GH peptides can modulate reverse cholesterol transport — linking GH secretagogues to cardiovascular lipid metabolism.
Why it matters
Relevant for ghrp, cardiovascular.
How the study worked
in-vitro study on ghrp, cardiovascular.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
A growth hormone-releasing peptide that binds scavenger receptor CD36 and ghrelin receptor up-regulates sterol transporters and cholesterol efflux in macrophages through a peroxisome proliferator-activated receptor gamma-dependent pathway.
Molecular endocrinology (Baltimore, Md.), 20(12), 3165-78
Citation
Avallone, Roberta; Demers, Annie; Rodrigue-Way, Amélie; Bujold, Kim; Harb, Diala; Anghel, Silvia; Wahli, Walter; Marleau, Sylvie; Ong, Huy; Tremblay, André. (2006). A growth hormone-releasing peptide that binds scavenger receptor CD36 and ghrelin receptor up-regulates sterol transporters and cholesterol efflux in macrophages through a peroxisome proliferator-activated receptor gamma-dependent pathway.. Molecular endocrinology (Baltimore, Md.), 20(12), 3165-78.