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Study breakdown

Atogepant Long-Term Safety and Efficacy for Migraine Prevention

evidence
The takeaway

Long-term study confirms atogepant safety, efficacy, and functional improvement for migraine prevention, supporting sustained use of this oral CGRP antagonist.

Key finding

Long-term study confirms atogepant safety, efficacy, and functional improvement for migraine prevent

What the researchers found

Long-term study confirms atogepant safety, efficacy, and functional improvement for migraine prevention, supporting sustained use of this oral CGRP antagonist.

Why it matters

Relevant to peptide therapeutics.

How the study worked

In publication.

What this study cannot tell us

In publication.

How to read the evidence

Based on design.

When this study was published

Published in 2025.

The bigger picture

Advances peptide evidence.

Questions still open

  • Long-term implications?
  • Evidence comparison?
  • Next steps?

Common questions

What does this mean?
Long-term study confirms atogepant safety, efficacy, and functional improvement for migraine prevention, supporting sustained use of this oral CGRP antagonist.
How reliable?
Consult publication.

Read the original research

Long-term safety, efficacy and functional outcomes of atogepant for the preventive treatment of migraine.

Cephalalgia : an international journal of headache, 45(8), 3331024251365206

Citation

Ashina, Sait; Ashina, Messoud; Holle-Lee, Dagny; Tassorelli, Cristina; Cho, Soo-Jin; He, Molly Yizeng; De Abreu Ferreira, Rosa; Gandhi, Pranav; Smith, Jonathan H; Pfleeger, Kimberly; Trugman, Joel M. (2025). Long-term safety, efficacy and functional outcomes of atogepant for the preventive treatment of migraine.. Cephalalgia : an international journal of headache, 45(8), 3331024251365206. https://doi.org/10.1177/03331024251365206