Systematic review of spreading depolarization's causes and consequences reveals CGRP release as a key link between cortical spreading depression and migraine pain activation.
Key findingSystematic review of spreading depolarization's causes and consequences reveals CGRP release as a ke
What the researchers found
Systematic review of spreading depolarization's causes and consequences reveals CGRP release as a key link between cortical spreading depression and migraine pain activation.
Why it matters
Relevant to peptide therapeutics.
The numbers in context
No specific numerical outcomes — systematic review of inflammatory mechanisms and mediators.
How the study worked
In publication.
Who was studied
Preclinical and clinical studies on neurological conditions involving spreading depolarization
What this study cannot tell us
In publication.
How to read the evidence
Based on design.
When this study was published
Published in 2025.
The bigger picture
Advances peptide evidence.
Questions still open
- Long-term implications?
- Evidence comparison?
- Next steps?
Common questions
What does this mean?
How reliable?
Read the original research
A systematic review of the causes and consequences of spreading depolarization in neuroinflammation; implications for neurovascular disorders.
Journal of neuroinflammation, 22(1), 178
Citation
Anwar, Faheem; Grech, Olivia; Mugo, Caroline W; Roberts, James A; Hubbard, Jessica C; Thomas, Chloe N; Sinclair, Alexandra J; Hill, Lisa J. (2025). A systematic review of the causes and consequences of spreading depolarization in neuroinflammation; implications for neurovascular disorders.. Journal of neuroinflammation, 22(1), 178. https://doi.org/10.1186/s12974-025-03503-6