ACE2 in Viral Infections and Neurodegeneration: The Dual Role of a Peptide Enzyme
Review of ACE2's dual role as both SARS-CoV-2 entry receptor and neuroprotective enzyme explores how viral infections and neurodegeneration intersect through this peptide-processing enzyme.
Quick Facts
What This Study Found
Review of ACE2's dual role as both SARS-CoV-2 entry receptor and neuroprotective enzyme explores how viral infections and neurodegeneration intersect through this peptide-processing enzyme.
Key Numbers
Review covers ACE2's roles in metabolizing angiotensin II and apelin-13, and the neurological consequences of SARS-CoV-2 spike protein binding.
How They Did This
In publication.
Why This Research Matters
Relevant to peptide therapeutics.
The Bigger Picture
Advances peptide therapeutic knowledge.
What This Study Doesn't Tell Us
In publication.
Questions This Raises
- ?Long-term implications?
- ?Comparison to evidence?
- ?Next research?
Trust & Context
- Key Stat:
- Key finding Review of ACE2's dual role as both SARS-CoV-2 entry receptor and neuroprotective enzyme explores how
- Evidence Grade:
- Based on study design.
- Study Age:
- Published in 2025.
- Original Title:
- The dual role of ACE2 in viral infections and neurodegeneration: mechanisms and therapeutic opportunities.
- Published In:
- Journal of neurovirology, 31(5), 397-406 (2025)
- Authors:
- Amelimojarad, Melika, Amelimojarad, Mandana
- Database ID:
- RPEP-09922
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What does this mean?
Review of ACE2's dual role as both SARS-CoV-2 entry receptor and neuroprotective enzyme explores how viral infections and neurodegeneration intersect through this peptide-processing enzyme.
How reliable?
Consult publication.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-09922APA
Amelimojarad, Melika; Amelimojarad, Mandana. (2025). The dual role of ACE2 in viral infections and neurodegeneration: mechanisms and therapeutic opportunities.. Journal of neurovirology, 31(5), 397-406. https://doi.org/10.1007/s13365-025-01282-7
MLA
Amelimojarad, Melika, et al. "The dual role of ACE2 in viral infections and neurodegeneration: mechanisms and therapeutic opportunities.." Journal of neurovirology, 2025. https://doi.org/10.1007/s13365-025-01282-7
RethinkPeptides
RethinkPeptides Research Database. "The dual role of ACE2 in viral infections and neurodegenerat..." RPEP-09922. Retrieved from https://rethinkpeptides.com/research/amelimojarad-2025-the-dual-role-of
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.