Review of ACE2's dual role as both SARS-CoV-2 entry receptor and neuroprotective enzyme explores how viral infections and neurodegeneration intersect through this peptide-processing enzyme.
Key findingReview of ACE2's dual role as both SARS-CoV-2 entry receptor and neuroprotective enzyme explores how
What the researchers found
Review of ACE2's dual role as both SARS-CoV-2 entry receptor and neuroprotective enzyme explores how viral infections and neurodegeneration intersect through this peptide-processing enzyme.
Why it matters
Relevant to peptide therapeutics.
The numbers in context
Review covers ACE2's roles in metabolizing angiotensin II and apelin-13, and the neurological consequences of SARS-CoV-2 spike protein binding.
How the study worked
In publication.
Who was studied
Review covering ACE2 biology in neurological health and SARS-CoV-2 infection
What this study cannot tell us
In publication.
How to read the evidence
Based on study design.
When this study was published
Published in 2025.
The bigger picture
Advances peptide therapeutic knowledge.
Questions still open
- Long-term implications?
- Comparison to evidence?
- Next research?
Common questions
What does this mean?
How reliable?
Read the original research
The dual role of ACE2 in viral infections and neurodegeneration: mechanisms and therapeutic opportunities.
Journal of neurovirology, 31(5), 397-406
Citation
Amelimojarad, Melika; Amelimojarad, Mandana. (2025). The dual role of ACE2 in viral infections and neurodegeneration: mechanisms and therapeutic opportunities.. Journal of neurovirology, 31(5), 397-406. https://doi.org/10.1007/s13365-025-01282-7